Results 171 to 180 of about 14,858,533 (317)

User-Centered Formative Evaluation of Cognitive Rehabilitation Software: Cognitive Walkthrough and System Usability Scale Study. [PDF]

JMIR Form Res
Hong S, Choi H, Kweon H.
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Formative Evaluation of an Early Family-Centred Prevention Programme for Childhood Overweight and Obesity (FruehstArt): A Study Protocol. [PDF]

Children (Basel)
Ruettger K, Fluegel V, Hagemeier A, Rosenberger KD, Hellmich M, Joisten C, Mause L, Scholten N, Glaubach J, Hehn M, Bernhard I, Redaèlli M, Simic D, Alayli A, Stock S, Dadaczynski K.   +15 more
europepmc   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Evaluation capacity building in a rural Victorian community service organisation: A formative evaluation. [PDF]

PLoS One
Kavanagh BE, Versace VL, Beks H, Dennis C, Binder MJ, Hernan AL, Namara KM.   +6 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

SiGerinn - interprofessional patient safety training in perinatal care: Concept and formative evaluation. [PDF]

GMS J Med Educ
Averdunk K, Hammerschmidt J, Klein A, Weigl M.   +3 more
europepmc   +1 more source

A developmental formative evaluation of a pilot participatory music program for veterans with housing insecurity. [PDF]

BMC Public Health, 2023
Wasmuth S, Rattray NA, Cheng P, Crow S, Myers J, Burns DS, Myers LJ, Hook B, Lustig A, Perkins AJ, Cheatham AJ, Bravata DM.   +11 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Implementation and formative evaluation of a peer-led chemsex intervention targeting sexualised crystal methamphetamine and GHB use: the M3THOD study. [PDF]

Harm Reduct J
Freestone J, Storer D, Siefried KJ, Bourne A, Prestage G, Ezard N, Maher L, Stirling R, Xiao BJ, Murphy D, Degenhardt L, Hammoud M.   +11 more
europepmc   +1 more source