Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
If you build it, will they come? A mixed-method formative evaluation of the start-up of a post-discharge clinic to improve care transitions. [PDF]
BMC Health Serv ResLee SY +13 more
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Usability and Feasibility of an In-Home Full-Color Imaging Scale for Remote Monitoring of High-Risk Patients With a History of Diabetic Foot Ulcers: Retrospective Observational Formative Evaluation. [PDF]
JMIR Form ResHu E +9 more
europepmc +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Strategic Governance of Artificial Intelligence-Enabled Clinical Algorithm Development: Formative Evaluation of the Semiautomatic Clinical Algorithm Development Framework. [PDF]
JMIR Form ResAhn SH, Kim J.
europepmc +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Implementing a Commercial AI Fracture Detection Tool in Health Care Using the Non-Adoption, Abandonment, Scale-Up, Spread, and Sustainability Framework: A Formative Evaluation Study. [PDF]
JMIR Form ResSeverinsen GH +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Usability, acceptability, and perceived relevance of the observatory of chronic health conditions of Santa Catarina: a formative evaluation. [PDF]
BMC Public HealthWill Castro LSEP +6 more
europepmc +1 more source