Results 111 to 120 of about 124,176 (345)

Dual antibiotherapy of tuberculosis mediated by inhalable locust bean gum microparticles [PDF]

open access: yes, 2017
Despite the existence of effective oral therapy, tuberculosis remains a deadly pathology, namely because of bacterial resistance and incompliance with treatments.
Alves, Ana D.   +7 more
core   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

open access: yesAdvanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang   +9 more
wiley   +1 more source

Validation of the XTT-test for assessing the antiproliferative activity of biologics on the basis of monoclonal antibodies

open access: yesБиопрепараты: Профилактика, диагностика, лечение, 2018
Using the example of Herceptin (Roche) a method of assessing the antiproliferative activity of monoclonal antibodies using tetrazolium salt was developed.
I. V. Lyagoskin   +5 more
doaj  

Cellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120 [PDF]

open access: yes, 2001
BACKGROUND: Cellulose acetate phthalate (CAP), a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the human immunodeficiency virus type 1 (HIV-1) and several herpesviruses. CAP formulations
A Boyum   +55 more
core   +3 more sources

Electrochemiluminescence Drives Photodynamic Therapy In Vivo

open access: yesAdvanced Science, EarlyView.
Electrochemiluminescence (ECL)‐driven photodynamic therapy (PDT) for in vivo cancer treatment is reported for the first time. The flexible ECL patch exhibits stable and intense luminance under alternating current voltage, enabling efficient photosensitization to generate reactive oxygen species that damage cancer cells, thus leading to significant ...
Jia‐Bao Lin   +5 more
wiley   +1 more source

Chitosan-Cellulose Composite for Wound Dressing Material. Part 2. Antimicrobial Activity, Blood Absorption Ability, and Biocompatibility [PDF]

open access: yes, 2014
Chitosan (CS), a polysaccharide derived from chitin, the second most abundant polysaccharide, is widely used in the medical world because of its natural and nontoxic properties and its innate ability for antibacterial and hemostasis effects.
Altiok   +46 more
core   +2 more sources

Cationic Boron Formazanate Complexes [PDF]

open access: yes, 2021
This thesis describes the synthesis and characterization of various three- and four-coordinate cationic and dicationic boron complexes supported by formazanate ([R1-N-N=C(Ph)-N=N-R5]− ligands. The first chapter provides a review of various three-coordinate and cationic boron complexes and related applications. Chapter two examines the effect of several
openaire  

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

open access: yesAdvanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao   +36 more
wiley   +1 more source

UJI SITOTOKSISITAS BAHAN CYANOACRYLATE VENEER DENGAN MTT ASSAY

open access: yesJournal of Dentistry Indonesia, 2015
The use of acrylic resin restoration basen on methyl methacrylate material in the dentistry, has already been replaced by composite because of certain poor characteristics. Recently, the restoration materials of methyl methacrylate have been re-developed,
Elly Munadziroh
doaj   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

open access: yesAdvanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He   +8 more
wiley   +1 more source

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