Results 61 to 70 of about 1,068,274 (302)
Reciprocal control of viral infection and phosphoinositide dynamics
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
IC 3418: Star Formation in a Turbulent Wake [PDF]
Galaxy Evolution Explorer observations of IC 3418, a low surface brightness galaxy in the Virgo Cluster, revealed a striking 17 kpc UV tail of bright knots and diffuse emission. H alpha imaging confirms that star formation is ongoing in the tail. IC 3418
Bigiel +29 more
core +4 more sources
Hematopoietic (stem) cells—The elixir of life?
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Research for innovative composite material solutions for impact absorbers is focused on the analysis of their ability to absorb impact energy. For this purpose, aramid fiber laminate with DCPD resin matrix was prepared.
Bocian Miroslaw +7 more
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
A Model for the Onset of Self-gravitation and Star Formation in Molecular Gas Governed by Galactic Forces: I. Cloud-scale Gas Motions [PDF]
Modern extragalactic molecular gas surveys now reach the scales of star-forming giant molecular clouds (GMCs, 20-50 pc). Systematic variations in GMC properties with galaxy environment imply that clouds are not universally self-gravitating objects ...
Bigiel, Frank +12 more
core +2 more sources
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Electrophoretic mobility of a charged colloidal particle: A computer simulation study
We study the mobility of a charged colloidal particle in a constant homogeneous electric field by means of computer simulations. The simulation method combines a lattice Boltzmann scheme for the fluid with standard Langevin dynamics for the colloidal ...
Allen M +12 more
core +2 more sources
In search of the authentic nation: landscape and national identity in Canada and Switzerland [PDF]
While the study of nationalism and national identity has flourished in the last decade, little attention has been devoted to the conditions under which natural environments acquire significance in definitions of nationhood.
Alter Peter +97 more
core +1 more source

