Results 71 to 80 of about 2,008,011 (306)

Supramolecular macrocycles reversibly assembled by Te…O chalcogen bonding

Nature Communications, 2016
Similarly to halogen bonding, the heavier chalcogens are capable of forming supramolecular links with electron rich sites. Here, the authors show that these forces can allow the formation of well-defined cyclic structures that are stable in solution and ...
Peter C. Ho, Patrick Szydlowski, Jocelyn Sinclair, Philip J. W. Elder, Joachim Kübel, Chris Gendy, Lucia Myongwon Lee, Hilary Jenkins, James F. Britten, Derek R. Morim, Ignacio Vargas-Baca   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Experimental and numerical analysis of aramid fiber laminates with DCPD resin matrix subjected to impact tests

MATEC Web of Conferences, 2017
Research for innovative composite material solutions for impact absorbers is focused on the analysis of their ability to absorb impact energy. For this purpose, aramid fiber laminate with DCPD resin matrix was prepared.
Bocian Miroslaw, Pach Joanna, Jamroziak Krzysztof, Kosobudzki Mariusz, Polak Slawomir, Pyka Dariusz, Kurzawa Adam, Kurowski Janusz   +7 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Army Ground Forces mobilization plan.

, 2020
Headquarters AGF has evolved a detailed mobilization plan for the expansion of the Army Ground Forces and Army Ground Force-type units from the projected numbers of units in existence in the Zone of Interior on 1 July 1946.
Headquarters, Army Ground Forces
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

In Situ Investigation of the Frictional Behaviour in Friction-Spinning

Journal of Manufacturing and Materials Processing
Friction-spinning is an incremental thermomechanical forming process that has huge potential due to its simple yet effective mechanism of utilising friction between a rotating workpiece and a forming tool to increase the workpiece’s temperature, which ...
Eugen Wiens, Dina Hijazi, Maik Jüttner, Werner Homberg, Mark Dennis Kensy, Wolfgang Tillmann   +5 more
doaj   +1 more source

Constrained design of sheet forming processes

MATEC Web of Conferences, 2016
New forming machines are typically incremental improvements on existing designs. Frequently tedious simulation and testing are required for insights on those possible improvements.
Loukaides Evripides G., Allwood Julian M.   +1 more
doaj   +1 more source