Results 111 to 120 of about 612,190 (327)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

On measuring the Tully-Fisher relation at $z > 1$

, 2006
The evolution of the line width - luminosity relation for spiral galaxies, the Tully-Fisher relation, strongly constrains galaxy formation and evolution models.
Moorwood, A. F. M., van der Werf, P. P., van Starkenburg, L., Yan, L.   +3 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Influence of Thickness On The Forming Limit Curve On Low Carbon Steel With Thickness of 0.7 mm and 0.8 mm

, 2022
Fikri Wahyu Pratama, Eddy S. Siradj, Okky Helja Octora Shahida Rhaman, Kahfi Ihza Mahendra   +3 more
openalex   +1 more source

Frequency-domain study of relaxation in a spin glass model for the structural glass transition

, 2003
We have computed the time-dependent susceptibility for the finite-size mean-field Random Orthogonal model (ROM). We find that for temperatures above the mode-coupling temperature the imaginary part of the susceptibility $\chi''(\nu)$ obeys the scaling ...
A Crisanti, Bengtzelius U., Bitko D., Bouchaud J. P., Brangian C., Brangian C., Cavagna A., Crisanti A., Crisanti A., Crisanti A., Crisanti A., F Rao, F Ritort, Götze W., Kauzmann W., Kudlik A., Leheny R. L., Leheny R. L., Marinari E., Rao F.   +19 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Artificial neural network-based prediction of complete forming limit curves for steel in sheet metal forming

Journal of Alloys and Metallurgical Systems
Forming Limit Curve (FLC) is crucial for predicting material formability and preventing defects in the sheet metal forming industry. Traditionally, FLCs are determined through Nakajima and Marciniak tests, which assess the material's response to various ...
Shivesh Kumar Sharan, Surajit Kumar Paul, Jyoti Kumari, Arijit Mondal   +3 more
doaj   +1 more source

On the Determination of the Forming Limits of Low-Alloy Steel Thin-Walled Tubes [PDF]

MATEC Web of Conferences
This paper presents an innovative methodology to determine the formability limits of low-alloy steel tubes, with particular attention to the effects of the weld line on their performance.
Magrinho João, Cruz Pedro, Sáenz-De-Argandoña Eneko, Mendiguren Joseba, Silva M. Beatriz   +4 more
doaj   +1 more source

The stellar and sub-stellar IMF of simple and composite populations

, 2012
The current knowledge on the stellar IMF is documented. It appears to become top-heavy when the star-formation rate density surpasses about 0.1Msun/(yr pc^3) on a pc scale and it may become increasingly bottom-heavy with increasing metallicity and in ...
A Duquennoy, A Maeder, A Parravano, A Sollima, A Sollima, A Stolte, A Vazdekis, A Vazdekis, AA Muench, AE Piskunov, AJ Cenarro, AN Belikov, AP Whitworth, AR Boss, AS Eddington, AT Myers, B Binggeli, B García, B Reipurth, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, BG Elmegreen, C Briceño, C Esteban, C Flynn, C Grillo, C Hayashi, C Koen, C Low, C Reylé, C Soubiran, C Weidner, C Weidner, C Weidner, C Weidner, C Weidner, C Weidner, C Weidner, C Yasui, CA Tout, CJ Clarke, CJ Grillmair, CJ Lada, CJ Lonsdale, CL Slesnick, CM Baugh, CM Boily, D Calzetti, D Gouliermis, D Gouliermis, D Stamatellos, D Stamatellos, D Stamatellos, D Stamatellos, D Vanbeveren, DA Fischer, DA Forbes, DA Tilley, DA Tilley, DC Heggie, DF Figer, DJ Pinfield, DJ Price, DR Weisz, E Brocato, E Casuso, E Corbelli, E Moraux, E Schilbach, E Vesperini, E Vesperini, EA Evstigneeva, EA Hoversten, EE Salpeter, F D’Antona, F Egusa, F Motte, F Najarro, F Palla, F Paresce, F Selman, FC Adams, FC Adams, FD Kahn, G Basri, G Bosch, G Chabrier, G Chabrier, G Chabrier, G Chabrier, G Chabrier, G Chabrier, G Duchêne, G Garcia-Segura, G Garcia-Segura, G Marchi de, G Marchi de, G Marchi De, G Piotto, G Weigelt, G Wuchterl, G Wuchterl, GE Miller, GR Blumenthal, GR Meurer, H Bartko, H Baumgardt, H Baumgardt, H Bouy, H Jahreiss, H Kirk, H Sana, H Zinnecker, H Zinnecker, HT Janka, I Baraffe, I Misgeld, I Thies, I Thies, I Thies, I Thies, IA Bonnell, IA Bonnell, IA Bonnell, IA Bonnell, IA Bonnell, IA Bonnell, IN Reid, IN Reid, IN Reid, IN Reid, J Binney, J Bouvier, J Dabringhausen, J Dabringhausen, J Dabringhausen, J Jijina, J Köppen, J Maíz Apellániz, J Maíz Apellániz, J Maíz Apellániz, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Pflamm-Altenburg, J Strader, JB Lamb, JC Tan, JD Neill, JE Dale, JE Gizis, JH Jeans, JJ Bochanski, JL Beuzit, JL Halbwachs, JM Kirk, JM Oliveira, JM Scalo, JN Bahcall, JP Anderson, JS Kalirai, JS Ulvestad, K Fuhrmann, K Kuijken, KD Finkelstein, KL Luhman, KL Luhman, KS Boer de, L Siess, L Testi, LA Hillenbrand, LA Hillenbrand, LJ Smith, LM Close, LR Penny, M Andersen, M Andersen, M Beech, M Dominik, M Fellhauer, M Fellhauer, M Fellhauer, M Fellhauer, M Fumagalli, M Haywood, M Mac Low, M Marks, M Marks, M Marks, M Marks, M Marks, M Marks, M Nagashima, M Ramspeck, M Schmalzl, M Schwarzschild, M Sirianni, MA Pérez-Torres, MG Wolfire, MJ Disney, MN Machida, MN Machida, MR Bate, MR Bate, MR Bate, MR Krumholz, MR Krumholz, MR Krumholz, MS Oey, MS Oey, N Bastian, N Ivanova, N Kevlahan, N Lodieu, N McCrady, N Moeckel, N Murray, N Phan-Bao, N Reid, N Rio Da, NC Hambly, NC Hambly, O Malkov, OY Malkov, P Girichidis, P Hennebelle, P Hennebelle, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Kroupa, P Massey, P Massey, P Padoan, P Padoan, P Wang, PA Crowther, PC Clark, PC Myers, PFL Maxted, PG Dokkum van, PG Dokkum van, PJE Peebles, PP Papadopoulos, PP Papadopoulos, PR Allen, R Chini, R Fuente Marcos de La, R Kudritzki, R Parra, R Wojtak, R Wünsch, RB Larson, RB Larson, RB Stothers, RC Kennicutt Jr, RJ Parker, RJ Parker, RJ Parker, RJ Smith, RJ White, RS Klessen, RS Klessen, RS Stobie, S Banerjee, S Basu, S Basu, S Bontemps, S Dib, S Dib, S Djorgovski, S Feltzing, S Hocuk, S Mieske, S Mieske, S Nayakshin, S Recchi, S Roychowdhury, S Röser, S Shen, S Zucker, SD Murray, SF Portegies Zwart, SJ Aarseth, SLW McMillan, SM Wilkins, SP Goodwin, SP Goodwin, SP Goodwin, SP Goodwin, SP Goodwin, SS Kim, SS Vogt, ST Megeath, T Chlebowski, T Hippel von, T Maschberger, T Maschberger, T Maschberger, T Onishi, T Peters, T Peters, T Preibisch, T Tsujimoto, TE Lutz, TJ Henry, TV Veltchev, U Löckmann, V Bromm, V Joergens, V Weidemann, VV Gvaramadze, VV Gvaramadze, W Jao, W-H Hsu, WJ Wit de, WJ Wit de, X Delfosse, X Delfosse, Y Li, Z-Y Li, Å Nordlund   +344 more
core   +1 more source