Results 121 to 130 of about 2,936,466 (288)

Predicting the fracture forming limit of 5754-O aluminum alloy by finite element simulation

Materials Research Express
Aluminum alloy has the advantages of low specific gravity, easy processing and good welding performance, so it is widely used on automobiles to achieve lightweighting.
Bin Yan, Guocheng Zhang, Xiaoli Liu, Xiaolin Yin   +3 more
doaj   +1 more source

Impact of Uniaxial Pre-Strains on the Forming Limit Curve (FLC) of CuZn 70-30 Brass Sheets for Enhanced Formability in Production Applications Using the Nakajima Test

Journal of Manufacturing and Materials Processing
Brass sheets are extensively utilized in the automotive, electrical, and other industries, where an in-depth understanding of their formability is crucial for achieving optimal performance in production applications. This study investigates the influence
Aseel Hamad Abed, Raed R. Shwaish, Asaad Ali Abbas, Baha S. Mahdi, Waleed Ahmed   +4 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

A novel mechanical attachment for biaxial tensile test: Application to formability evaluation for DP590 at different temperatures

Journal of Materials Research and Technology
A novel mechanical attachment for conducting in-plane biaxial tensile test is provided in this paper. In this attachment, the conversion of force from an external actuator into two pairs of orthogonal forces is achieved by specially designed trapezoidal ...
Zhihao Wang, Xingrong Chu, Zhenming Yue, Lionel Leotoing, Jun Gao   +4 more
doaj   +1 more source

FRICTION TECHNIQUE FOR DETERMINING FORMING LIMIT CURVES [PDF]

Al-Rafidain Engineering Journal (AREJ), 2006
null A. Alsaati, null W. J.Ali, null F. M.Alkaissy   +2 more
openaire   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The effect of strain rate on position of forming limit curve

, 2020
Diplomová práce se zabývá vlivem rychlosti deformace na zásobu plasticity materiálů. Teoretická část pojednává o tváření se zaměřením na hodnocení tvářitelnosti pomocí FLD diagramů, které jsou nezbytné pro návrh lisovacích operací, a to zejména v ...
Ondřej Hák
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source