Results 111 to 120 of about 2,936,466 (288)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
MetalsHigh-strength steels such as Dual Phase (DP), Transformation-Induced Plasticity (TRIP), and Twinning-Induced Plasticity (TWIP) steels have gained importance in automotive applications due to the potential for weight reduction and increased performance in
Luis Fernando Folle +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Numerical Simulation of the Forming Limit of Superplastic AZ31B Magnesium Alloy Sheet
, 2017 Numerical simulation of superplastic forming limit of AZ31B magnesium alloy sheet was investigated. The damage evolution equation based on the law of the micro-damage evolution and statistical mechanics was derived, and damage characteristic parameters ...
Xiao Dong Luo +4 more
core +1 more source
International Journal of Lightweight Materials and ManufactureArtificial neural network models were developed to estimate forming limit diagrams from tensile test results based on our own experiments and data from the literature for steel and aluminium sheet metals.
Imre Czinege, Dóra Harangozó
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Effects of Vibrations on Metal Forming Process: Analytical Approach and Finite Element Simulations [PDF]
, 2010 Vibration assisted forming is one of the most recent and beneficial technique used to improve forming process. Effects of vibration on metal forming processes can be attributed to two causes.
ABBA, Gabriel +3 more
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