Results 111 to 120 of about 1,062 (237)

Effect of microstructure and deformation mechanisms on the forming limit curve of automotive steels and aluminium alloys

International Journal of Lightweight Materials and Manufacture
Increased crashworthiness and lightweighting are key factors influencing material development in the automotive sector. Aluminium alloys and advanced high-strength steels (AHSS) are extensively used in the automotive industry because of their exceptional
Surajit Kumar Paul
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A New Phenomenological Model to Predict Forming Limit Curves from Tensile Properties for Hot-Rolled Steel Sheets

A phenomenological model for the prediction of the forming limit curve (FLC) based on basic mechanical properties through a uniaxial tensile test can tremendously shorten the design time of the forming process and reduce the measuring costs.
Hong-Wu Song, Si-Ying Deng, Shuai-Feng Chen, Zheng Cai, Wei-Jin Chen, Yong Xu, Xin-Hua Pei, Shi-Hong Zhang   +7 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Numerical determination of the forming limit diagram for thin sheet metal foil from a ductile damage model identified via Micro-Single Point Incremental Forming tests

, 2016
International audienceIn this paper, the micro-formability of thin sheets is investigated by a numerical approach. A coupled elastic-plastic-damage model is used to predict forming limit diagram according to the micro-Marciniak tests.
Thibaud, Sébastien, Malecot, Pierrick, Hapsari, Gemala, Hmida, Ramzi, Richard, Fabrice   +4 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Elevated temperature forming limit strain diagrams of automotive alloys Al6014-T4 and DP600: A case study

, 2016
The press formability of the automotive materials such as aluminum alloys, magnesium alloys and steels is influenced by forming temperatures. While adjusting the temperature level of die, punch and binder, the lightweight materials can successfully be ...
Drotleff, Klaus, Saxena, Krishna Kumar, Mukhopadhyay, Jyoti   +2 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Application of artificial neural networks for characterisation of formability properties of sheet metals

International Journal of Lightweight Materials and Manufacture
Artificial neural network models were developed to estimate forming limit diagrams from tensile test results based on our own experiments and data from the literature for steel and aluminium sheet metals.
Imre Czinege, Dóra Harangozó
doaj   +1 more source