Results 91 to 100 of about 1,062 (237)
A biaxial test for rheological and formability identification
EPJ Web of Conferences, 2010 Accurate constitutive laws and formability limits of materials are essential for a numerical optimization of sheet forming processes. The main objective of this work is to develop a new experimental device able to give for a unique specimen a good ...
Ragneau E. +3 more
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Forming Limit Analyses of Cold Rolled IF Steel Sheet Using Differential Work Hardening Model
, 2014 A servo-controlled multiaxial tube expansion testing machine was used to measure the multiaxial plastic deformation behavior of a cold rolled IF steel sheet for a range of strain from initial yield to fracture.
Hakoyama, Tomoyuki, Kuwabara, Toshihiko
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Prediction of Forming Limit Curves for 2021 Aluminum Alloy
Procedia Engineering, 2017 Abstract The forming limit curve (FLC) is a line that is consisted of the major and minor strain pairs for variety kinds of strain paths. It has been widely adopted as a practical criterion in evaluating the formability of different sheet metals. Predicting FLC numerically could avoid the drawbacks of time-consuming and hard-sledding effectively ...
Wennan Yuan, Min Wan, Xiangdong Wu
openaire +1 more source
The effect of strain rate on position of forming limit curve
, 2020 Diplomová práce se zabývá vlivem rychlosti deformace na zásobu plasticity materiálů. Teoretická část pojednává o tváření se zaměřením na hodnocení tvářitelnosti pomocí FLD diagramů, které jsou nezbytné pro návrh lisovacích operací, a to zejména v ...
Ondřej Hák
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Prediction of forming limit curve for pure titanium sheet
Transactions of Nonferrous Metals Society of China, 2018 Abstract Commercially pure titanium (CP Ti) has been actively used in the plate heat exchanger due to its light weight, high specific strength, and excellent corrosion resistance. However, researches for the plastic deformation characteristics and press formability of the CP Ti sheet are not much in comparison with automotive steels and aluminum ...
Young-Suk KIM +2 more
openaire +1 more source
On the use of stress-based forming limit curve for forming and fracture
, 2008 The forming limit curve (FLC) or diagram illustrates the major and minor strains expected on the surface of a deforming sheet material at the onset of local necking.
Yoon, Jeong Whan +3 more
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