Results 91 to 100 of about 2,936,466 (288)
Comparison between incremental deformation theory and flow rule to simulate sheet-metal forming processes [PDF]
, 2012 Numerical simulation of the deep drawing process for the manufacture of aeronautical or automotive components should predict with good accuracy the behaviour during the forming operation, taking into account, the material and the process parameters ...
BATOZ, Jean-Louis +3 more
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Development of novel forming limit curve testing method
IOP Conference Series: Materials Science and Engineering, 2018 A new concept of the forming limit curve testing method has been developed for evaluating sheet metal formability. This new method complies with the current ISO 12004-2 standard, and has been verified by the numerical analysis in terms of specimen deformation, strain path characterization and lubrication effect. It combines the advantages from both the
Z Deng, J P McGuire
openaire +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2012 Colour photograph of the completed Curve which looms large next to the older buildings of the ...
Hyde, Colin;
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Microstructure Evolution and Material Flow of Steel in Semi-solid Forming Process [PDF]
, 2011 The present study aims to identify and characterize the development of microstructure and deformation characteristics of steel grades in semi-solid state which is affected by the change in morphologies of microstructure at high temperature ...
GU, Guochao +4 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
, 2014 Colour photograph of the interior of the Curve Theatre, Leicester, showing lighting equipment in the stage ...
Barnes, Amy
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