Results 131 to 140 of about 71,625 (304)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Numerical determination of the forming limit diagram for thin sheet metal foil from a ductile damage model identified via Micro-Single Point Incremental Forming tests

, 2016
International audienceIn this paper, the micro-formability of thin sheets is investigated by a numerical approach. A coupled elastic-plastic-damage model is used to predict forming limit diagram according to the micro-Marciniak tests.
Thibaud, Sébastien, Malecot, Pierrick, Hapsari, Gemala, Hmida, Ramzi, Richard, Fabrice   +4 more
core  

A Review on Sheet Metal Forming Behavior in High-Strength Steels and the Use of Numerical Simulations

Metals
High-strength steels such as Dual Phase (DP), Transformation-Induced Plasticity (TRIP), and Twinning-Induced Plasticity (TWIP) steels have gained importance in automotive applications due to the potential for weight reduction and increased performance in
Luis Fernando Folle, Tiago Nunes Lima, Matheus Passos Sarmento Santos, Bruna Callegari, Bruno Caetano dos Santos Silva, Luiz Gustavo Souza Zamorano, Rodrigo Santiago Coelho   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Stretch-forming characteristics of austenitic material stainless steel 304 at hot working temperatures

High Temperature Materials and Processes
The need for sheet metal forming using highly resistant materials such as titanium alloys and stainless steel has increased recently. These materials possess elevated mean flow stress values, which make them difficult to draw at room temperature.
Lakshmi Akkireddy Anitha, Bandhu Din, Kumar Ashish, Chandrashekar Rakesh   +3 more
doaj   +1 more source

Experimental and Numerical Investigation of Forming Limit Diagrams during Single Point Incremental Forming for Al/Cu Bimetallic Sheets

Metals
This article investigated the formability of aluminum/copper bimetal sheets during single-point incremental forming. First, the two-layer sheets were produced by the explosive welding process; then, the rolling process was performed with 50% strain on ...
Payam Tayebi, Amir Reza Nasirin, Habibolah Akbari, Ramin Hashemi   +3 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Evaluation of Forming Limit Diagram of aluminum alloy 6061-T6 at ambient temperature

, 2015
As fuel price increases, automobile industries are looking for more fuel efficient cars with less carbon emissions and high crashworthiness. Accordingly, this has necessitated for further research into the formability of Al 6xxx series alloys that have ...
Mukhopadhyay, J., Sharma, Manoj K.
core  

Forming limit diagram of annealed copper OFE thick sheets for optimized hydroforming of superconducting RF cavities

Materials & Design
Coated superconducting radio-frequency (SRF) cavities are planned to be implemented in the Future Circular Collider (FCC) at the European Organization for Nuclear Research (CERN).
Adrià Gallifa-Terricabras, Joanna Sylwia Swieszek, Dorota Smakulska, Berta Ruiz-Palenzuela, Marco Garlaschè   +4 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source