Results 121 to 130 of about 2,512,776 (299)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Experimental and Numerical Investigation of Forming Limit Diagrams during Single Point Incremental Forming for Al/Cu Bimetallic Sheets

Metals
This article investigated the formability of aluminum/copper bimetal sheets during single-point incremental forming. First, the two-layer sheets were produced by the explosive welding process; then, the rolling process was performed with 50% strain on ...
Payam Tayebi, Amir Reza Nasirin, Habibolah Akbari, Ramin Hashemi   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A Shear Fracture Criterion to Predict Limit Strains in Sheet Metal Forming

, 2018
Present work examines a mathematical model to predict the onset of shear fracture in the industrial processes of sheet metal forming such as biaxial stretching.
Barlat, F, Bressan, JD
core   +1 more source

Forming limit diagram of annealed copper OFE thick sheets for optimized hydroforming of superconducting RF cavities

Materials & Design
Coated superconducting radio-frequency (SRF) cavities are planned to be implemented in the Future Circular Collider (FCC) at the European Organization for Nuclear Research (CERN).
Adrià Gallifa-Terricabras, Joanna Sylwia Swieszek, Dorota Smakulska, Berta Ruiz-Palenzuela, Marco Garlaschè   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Study on Forming Limit of Tubes

, 2003
The objective of this study is to establish the Forming Limit Diagram (FLD) of tubes. An experimental system of tube hydroforming, the electrical chemical etching method and the image process system are used to carry out the sheet metal forming test and ...
Lin, Jui-Chang
core  

Stretch-forming characteristics of austenitic material stainless steel 304 at hot working temperatures

High Temperature Materials and Processes
The need for sheet metal forming using highly resistant materials such as titanium alloys and stainless steel has increased recently. These materials possess elevated mean flow stress values, which make them difficult to draw at room temperature.
Lakshmi Akkireddy Anitha, Bandhu Din, Kumar Ashish, Chandrashekar Rakesh   +3 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Numerical determination of the forming limit diagram for thin sheet metal foil from a ductile damage model identified via Micro-Single Point Incremental Forming tests

, 2016
International audienceIn this paper, the micro-formability of thin sheets is investigated by a numerical approach. A coupled elastic-plastic-damage model is used to predict forming limit diagram according to the micro-Marciniak tests.
Thibaud, Sébastien, Malecot, Pierrick, Hapsari, Gemala, Hmida, Ramzi, Richard, Fabrice   +4 more
core