Results 121 to 130 of about 71,625 (304)
Forming Limit Diagram Generation of Aluminum Alloy AA2014 Using Nakazima Test Simulation Tool
, 2016 Plastic instability is a commonly observed problem, in sheet metal forming operation, which leads to defective products. Forming Limit Diagram (FLD) is an important parameter to be considered in the manufacturing process of non-defective sheet products ...
Anjaneyulu, C. +2 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Press forming limit of ductile metal sheet
, 2020 Transport equipment such as cars and aircraft are working to reduce weight. A common practice is to build the structure from lightweight materials. So far, attention has been focused on multi-materials that properly use lightweight materials that are ...
氏原 創志
core
On predicting the forming limit diagram for automotive aluminium sheet
, 1998 Aluminum has considerable potential as a material for automotive panels. The ability to predict forming limit diagrams accurately for aluminum is important for preventing failure in the forming process.
Weinmann, K. J., Xu, Siguang
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Study on Forming Limit of Tubes
, 2003 The objective of this study is to establish the Forming Limit Diagram (FLD) of tubes. An experimental system of tube hydroforming, the electrical chemical etching method and the image process system are used to carry out the sheet metal forming test and ...
Lin, Jui-Chang
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2011 Son yıllarda otomotiv endüstrisinde yüksek mukavemetli çeliklerin kullanımında hızlı bir artış görülmektedir. Bu çelikler arasında da yüksek mukavemet ve iyi şekillenebilirlik özelliklerinden dolayı iki fazlı çelikler çok fazla ilgi görmektedir.
Uysal, Emrah
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source