Results 101 to 110 of about 71,625 (304)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Experimental analysis for defining forming limit diagram for thick sheets

, 2014
In this paper a combined procedure to determine the forming limit diagram (Keeler-Goodwin diagram) for thick sheets is proposed. It is defined for cold rolled steel sheet Č0147 (RSt 13 DIN 17006) with thickness of 5 mm using two different criteria ...
Cvetkov, Slavco, Kocov, Atanas
core  

Predicting the fracture forming limit of 5754-O aluminum alloy by finite element simulation

Materials Research Express
Aluminum alloy has the advantages of low specific gravity, easy processing and good welding performance, so it is widely used on automobiles to achieve lightweighting.
Bin Yan, Guocheng Zhang, Xiaoli Liu, Xiaolin Yin   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Shear Fracture Criterion to Predict Limit Strains in Sheet Metal Forming

, 2018
Present work examines a mathematical model to predict the onset of shear fracture in the industrial processes of sheet metal forming such as biaxial stretching.
Barlat, F, Bressan, JD
core   +1 more source

Comparison of nonlinear strain path correction models for the FLD characterization [PDF]

MATEC Web of Conferences
The Forming Limit Diagram (FLD), along with the Forming Limit Curve (FLC) it encompasses, are widely used tools in sheet metal forming to predict the forming behavior of sheet metal.
Mainguy Grégoire, Balan Tudor, Lemoine Xavier   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

EXPERIMENTAL CONSIDERATION OF LIMIT STRAIN IN THE FORMING LIMIT DIAGRAM OF A DUCTILE METAL SHEET

, 2016
In the research and development in recent years of the vehicle structure weight saving technology is a multi-material reduction is proceeding to use the some of the lightweight material to the right man in the right place.
福山 俊介
core  

Determination of Buckling limit Diagram for Metal Sheets

Journal of Engineering and Sustainable Development, 2013
Sheet buckling a form of instability, is undesirable in final products as it contributes a decrease in part stiffness and affects part appearance and assembly.
Amer Yahya M. Aljarjees
doaj