Results 101 to 110 of about 2,512,776 (299)

Forming limit curves for quasi-static and dynamic working-media-based forming processes [PDF]

, 2018
The production of complex, multi-functional, high-strength components is becoming increasingly important in the sheet metal industry. Especially with small batch sizes, quasi-static working-media-based forming processes (WMF), such as hydromechanical ...
Djakow, E., Homberg, W., Springer, R.
core   +1 more source

Hydromechanical Deep Drawing Process and Optimization of Fender Based on FEM

Journal of Harbin University of Science and Technology, 2018
Aiming at the problem of failure and insufficient drawing when stamping forming for complex structure parts，we conduct numerical simulation of hydromechanical deep drawing to automobile front fender.
LIU Xiao-jing, TANG Xian-lin, ZHANG Xiao-hua, WANG Fei   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Forming limit diagram of an ultra-thin commercially pure titanium sheet: Combined experimental–numerical approach

Journal of Materials Research and Technology
This study presents a methodology for determining the forming limit diagram (FLD) of an ultra-thin (0.1 mm) commercially pure titanium (CP–Ti) sheet developed for use in metallic bipolar plates for fuel cells.
Kyung Mun Min, Chanyang Kim, Seonghwan Choi, Jong-Hwa Hong, Jinwoo Lee, Hyuk Jong Bong   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Experimental and theoretical formability analysis using strain and stress based forming limit diagram for advanced high strength steels

, 2018
In this study, experimental and numerical analyses of Forming Limit Diagram (FLD) and Forming Limit Stress Diagram (FLSD) for two Advanced High Strength Steel (AHSS) sheets grade DP780 and TRIP780 were performed.
Barlat, F, Suranuntchai, S, Panich, S, Uthaisangsuk, V, Jirathearanat, S   +4 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Forming limit diagram prediction of 6061 aluminum by GTN damage model

, 2018
Forming limit diagram (FLD) is one of the formability criteria which is a plot of major strain versus minor strain. In the present study, Gurson-Tvergaard-Needleman (GTN) model is used for FLD prediction of aluminum alloy 6061.
Rasoul Safdarian
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source