Results 91 to 100 of about 71,625 (304)

Strain Path Influence on Formability and Microstructural Evolution of IFHS Steel via Miniature LDH Test [PDF]

MATEC Web of Conferences
This work investigates effect of strain path on the forming behaviour and microstructural evolution of Interstitial Free High Strength (IFHS) steel using miniature Limiting Dome Height (LDH) test.
Kumar Pavan, Mahajan Peeyush, Mishra Sushil K., Datta Rahul, Narasimhan K.   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Experimental and theoretical formability analysis using strain and stress based forming limit diagram for advanced high strength steels

, 2018
In this study, experimental and numerical analyses of Forming Limit Diagram (FLD) and Forming Limit Stress Diagram (FLSD) for two Advanced High Strength Steel (AHSS) sheets grade DP780 and TRIP780 were performed.
Barlat, F, Suranuntchai, S, Panich, S, Uthaisangsuk, V, Jirathearanat, S   +4 more
core   +1 more source

Investigation into the Hot-Forming Limit for 22MnB5 Hot-Forming Steel under a Stamping Process

Metals
Hot-forming technology for 22MnB5 hot-forming steel (22MnB5 HF steel) plates has been widely used in the automobile manufacturing industry in recent years.
Wenwu He, Bin Yang, Xuezhong Zhang, Min Li, Shuli Sun, Bao Wang, Qingxian Ma   +6 more
doaj   +1 more source

Formability limits, damage and fracture mechanisms in AA5182 Al-Mg sheets formed under subzero temperature conditions [PDF]

MATEC Web of Conferences
The applicability of in demand lightweight Al-Mg alloys is constrained by limited formability and surface defects caused by the Portevin-Le Chatelier (PLC) effect, which manifests as serrated plastic flow due to dynamic strain aging.
Magliaro John, Behtash Amir M. K., Alpas Ahmet T.   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Forming limit diagram prediction of 6061 aluminum by GTN damage model

, 2018
Forming limit diagram (FLD) is one of the formability criteria which is a plot of major strain versus minor strain. In the present study, Gurson-Tvergaard-Needleman (GTN) model is used for FLD prediction of aluminum alloy 6061.
Rasoul Safdarian
core   +1 more source

Failure analysis based on microvoid growth for sheet metal during uniaxial and biaxial tensile tests [PDF]

, 2013
The aim of the presented investigations is to perform an analysis of fracture and instability during simple and complex load testing by addressing the influence of ductile damage evolution in necking processes.
Abbassi, Fethi, Mistou, Sébastien, Zghal, Ali   +2 more
core   +1 more source

Numerical Simulation and Parametric Investigation ofIncremental Sheet Forming Process for MultilayerSandwich Panels

International Journal of Emerging Engineering and Technology
The multifunctional structure, i.e., multilayer sandwich panel (MLSP), exhibits properties like high rigidity, good specific strength, and lightweight and thermal resistance.
Abdul Hameed Khan, Nasir Hayat, Hazrat Bilal   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source