Results 91 to 100 of about 2,512,776 (299)

Research on Forming Limit Stress Diagram of Advanced High Strength Dual-Phase Steel Sheets

, 2023
The Forming Limit Stress Diagram (FLSD) can accurately describe the forming process of high-strength steel. However, obtaining FLSD is relatively difficult.
Hongjian Cui, Di Li, Zipeng Lu, Jiachuan Xu, Ning Jiang, Qiutao Fu   +5 more
core   +1 more source

Predicting the fracture forming limit of 5754-O aluminum alloy by finite element simulation

Materials Research Express
Aluminum alloy has the advantages of low specific gravity, easy processing and good welding performance, so it is widely used on automobiles to achieve lightweighting.
Bin Yan, Guocheng Zhang, Xiaoli Liu, Xiaolin Yin   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Forming Limit of Holed Dome in Two-Stage Stretch Forming

, 2010
This paper deals with the accurate prediction of forming limit of a dome with a circular hole in two-stage stretch forming. Since this two-stage forming is a process of non-proportional deformation, a fracture criterion, which is capable to predict ...
Ryutaro Hino, Atsushi Hirahara, Fusahito Yoshida   +2 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Forming Limit Stress Diagram Prediction of Pure Titanium Sheet Based on GTN Model

, 2019
In this paper, the initial values of damage parameters in the Gurson–Tvergaard–Needleman (GTN) model are determined by a microscopic test combined with empirical formulas, and the final accurate values are determined by finite element reverse
Mei Zhan, Fuxiao Chen, Junqing Guo, Luge Bai, Yanyang Li, Zhuo Song, Tao Huang, Kun Wang   +7 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Determination of Buckling limit Diagram for Metal Sheets

Journal of Engineering and Sustainable Development, 2013
Sheet buckling a form of instability, is undesirable in final products as it contributes a decrease in part stiffness and affects part appearance and assembly.
Amer Yahya M. Aljarjees
doaj  

Comparison of nonlinear strain path correction models for the FLD characterization [PDF]

MATEC Web of Conferences
The Forming Limit Diagram (FLD), along with the Forming Limit Curve (FLC) it encompasses, are widely used tools in sheet metal forming to predict the forming behavior of sheet metal.
Mainguy Grégoire, Balan Tudor, Lemoine Xavier   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source