Results 71 to 80 of about 71,625 (304)

An Analysis of Forming Limit in Micro Deep Drawing of the Square Cup for Anisotropic Foil

, 2014
This paper presents an explicit dynamic finite element method (FEM) in conjunction with the forming limit diagram (FLD) to analyze the forming limit for the SPCC foil in micro deep drawing of square cup. In the present study, the tensile, anisotropic and
Yeh, F.-H., Yeh, F.-H.; Li, C.-L.; Tsay, K.-N., Yeh, Fung Huei; Li, Ching Lun; Tsay, Kun Nan   +2 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

STUDY THE EFFECTS OF PRESTRAINS IN UNIAXIAL TENSION ON THE FORMING LIMIT DIAGRAM OF ALUMINUM ALLOY SHEETS(2024 T3)

Tikrit Journal of Engineering Sciences, 2015
          The strain path for sheet metal may be changed during forming , this may be affect the forming limit curve (FLC) . In this work the FLC before and after prestraining was determined for aluminum alloy (2024 T3) to study the effect of this type ...
Waleed J. Ali, Thaer F. Ahmed
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Determination of the forming limit diagram of zinc electro-galvanized steel sheets

Metalurgija, 2012
Forming limit curves (FLC) of deep drawing steel sheets have been determined experimentally and calculated on the base of the material tensile properties following the Hill, Swift, Marciniak-Kuczyński and Sing-Rao methods.
W. Fracz, F. Stachowicz
doaj  

Effects of layer arrangement, pin size, polyurethane thickness, and polyurethane hardness on forming limits of Al/Cu bimetallic sheets through multi-point forming process

Journal of Materials Research and Technology
This study experimentally evaluated the forming limit diagram (FLD) of Al/Cu bimetallic sheets fabricated using explosive welding in multi-point forming.
Milad Aali Majidabad, Ramin Hashemi, Habibolah Akbari   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Forming Limit of Holed Dome in Two-Stage Stretch Forming

, 2010
This paper deals with the accurate prediction of forming limit of a dome with a circular hole in two-stage stretch forming. Since this two-stage forming is a process of non-proportional deformation, a fracture criterion, which is capable to predict ...
Ryutaro Hino, Atsushi Hirahara, Fusahito Yoshida   +2 more
core   +1 more source