Results 61 to 70 of about 71,352 (265)

Evaluation of the formability of 90/10 brass produced by different casting processes and investigation of the effect of Forming Limit Diagram determination procedure

Journal of Materials Research and Technology, 2019
The present work investigated the formability of 1.1 mm thick sheets of 90/10 brass (UNS C22000) alloy obtained by two different process routes: continuous casting (CC) and semi-continuous casting (SCC).
Leandro de Almeida, Cláudio Geraldo Schön   +1 more
doaj   +1 more source

Detection of delamination of steel-polymer sandwich composites using acoustic emission and development of a forming limit diagram considering delamination. [PDF]

Heliyon, 2023
Yang J, Han S, Yu WR.
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Formability limits, damage and fracture mechanisms in AA5182 Al-Mg sheets formed under subzero temperature conditions [PDF]

MATEC Web of Conferences
The applicability of in demand lightweight Al-Mg alloys is constrained by limited formability and surface defects caused by the Portevin-Le Chatelier (PLC) effect, which manifests as serrated plastic flow due to dynamic strain aging.
Magliaro John, Behtash Amir M. K., Alpas Ahmet T.   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Investigation into the Hot-Forming Limit for 22MnB5 Hot-Forming Steel under a Stamping Process

Metals
Hot-forming technology for 22MnB5 hot-forming steel (22MnB5 HF steel) plates has been widely used in the automobile manufacturing industry in recent years.
Wenwu He, Bin Yang, Xuezhong Zhang, Min Li, Shuli Sun, Bao Wang, Qingxian Ma   +6 more
doaj   +1 more source

Strain Path Influence on Formability and Microstructural Evolution of IFHS Steel via Miniature LDH Test [PDF]

MATEC Web of Conferences
This work investigates effect of strain path on the forming behaviour and microstructural evolution of Interstitial Free High Strength (IFHS) steel using miniature Limiting Dome Height (LDH) test.
Kumar Pavan, Mahajan Peeyush, Mishra Sushil K., Datta Rahul, Narasimhan K.   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Numerical Simulation and Parametric Investigation ofIncremental Sheet Forming Process for MultilayerSandwich Panels

International Journal of Emerging Engineering and Technology
The multifunctional structure, i.e., multilayer sandwich panel (MLSP), exhibits properties like high rigidity, good specific strength, and lightweight and thermal resistance.
Abdul Hameed Khan, Nasir Hayat, Hazrat Bilal   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source