Results 81 to 90 of about 2,512,776 (299)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Investigation into the Hot-Forming Limit for 22MnB5 Hot-Forming Steel under a Stamping Process

Metals
Hot-forming technology for 22MnB5 hot-forming steel (22MnB5 HF steel) plates has been widely used in the automobile manufacturing industry in recent years.
Wenwu He, Bin Yang, Xuezhong Zhang, Min Li, Shuli Sun, Bao Wang, Qingxian Ma   +6 more
doaj   +1 more source

Formability limits, damage and fracture mechanisms in AA5182 Al-Mg sheets formed under subzero temperature conditions [PDF]

MATEC Web of Conferences
The applicability of in demand lightweight Al-Mg alloys is constrained by limited formability and surface defects caused by the Portevin-Le Chatelier (PLC) effect, which manifests as serrated plastic flow due to dynamic strain aging.
Magliaro John, Behtash Amir M. K., Alpas Ahmet T.   +2 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Numerical Simulation and Parametric Investigation ofIncremental Sheet Forming Process for MultilayerSandwich Panels

International Journal of Emerging Engineering and Technology
The multifunctional structure, i.e., multilayer sandwich panel (MLSP), exhibits properties like high rigidity, good specific strength, and lightweight and thermal resistance.
Abdul Hameed Khan, Nasir Hayat, Hazrat Bilal   +2 more
doaj   +1 more source

Strain Path Influence on Formability and Microstructural Evolution of IFHS Steel via Miniature LDH Test [PDF]

MATEC Web of Conferences
This work investigates effect of strain path on the forming behaviour and microstructural evolution of Interstitial Free High Strength (IFHS) steel using miniature Limiting Dome Height (LDH) test.
Kumar Pavan, Mahajan Peeyush, Mishra Sushil K., Datta Rahul, Narasimhan K.   +4 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Simulation and Experimental Study on Roll-Forming Limit of Cup

, 2022
Roll forming can improve the material utilization rate and production efficiency of cups with a curved rotary profile, but there is no basis for the determination of forming limit. The DEFORM-3D software was used to simulate the roll forming of cups. The
Zeng Wei, Xubin Li, Shengpeng Ning, Yali Duan, Baohong Zhang, Yongbiao Yang   +5 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source