Results 111 to 120 of about 71,625 (304)
Hydromechanical Deep Drawing Process and Optimization of Fender Based on FEM
Journal of Harbin University of Science and Technology, 2018 Aiming at the problem of failure and insufficient drawing when stamping forming for complex structure parts，we conduct numerical simulation of hydromechanical deep drawing to automobile front fender.
LIU Xiao-jing +3 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
A Triaxial Failure Diagram to predict the forming limit of 3D sheet metal parts subjected to multiaxial stresses [PDF]
, 2016 Accurate prediction of failure and forming limits is essential when modelling sheet metal forming processes. Since traditional Forming Limit Curves (FLCs) are not valid for materials subjected to triaxial loading, a new failure criterion is proposed in ...
Socorro Miranda, Gerardo +3 more
core +1 more source
Journal of Materials Research and TechnologyThis study presents a methodology for determining the forming limit diagram (FLD) of an ultra-thin (0.1 mm) commercially pure titanium (CP–Ti) sheet developed for use in metallic bipolar plates for fuel cells.
Kyung Mun Min +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Calculation of the forming limit curve at fracture
, 2017 The prediction of the forming limit diagram at fracture (FLDF) is of great importance specially for the cases where forming is controlled by fracture instead of necking. A physical model of coalescence is proposed in two cases of internal damage:
J.M. Jalinier
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Pre-Straining Operation : Prediction of Strain Paths Within a Forming Limit Diagram
, 2022 In a Sheet Metal Forming (SMF) operation, complex geometries in multi-stage forming processes are mostly common. Forming a blank, major and minor straining willoccur.
Olofsson, Elin, Al-Fadhli, Mohammed
core
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source