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Spray drying of budesonide, formoterol fumarate and their composites—I. Physicochemical characterisation

International Journal of Pharmaceutics, 2009
The objective of this work was to examine the physicochemical properties of spray dried budesonide, formoterol fumarate and their mixtures at two different weight ratios: 100:6 and 400:6 of budesonide and formoterol fumarate, respectively. A comparison of the thermal properties, crystalline/amorphous nature and particle size of the starting micronised ...
L, Tajber   +3 more
openaire   +2 more sources

Bioequivalence of Inhaled Formoterol Fumarate Assessed from Pharmacodynamic, Safety and Urinary Pharmacokinetic Data

Arzneimittelforschung, 2011
This paper deals with a crossover trial on healthy volunteers performed to obtain combined pharmacodynamic, safety and pharmacokinetic data in order to assess the bioequivalence of formoterol fumarate (CAS 43229-80-7) delivered by mono-dose dry powder inhalers, as test and reference.
MARZO A   +8 more
openaire   +3 more sources

Fluticasone propionate/formoterol fumarate in fixed-dose combination for the treatment of asthma

Expert Review of Respiratory Medicine, 2014
A new combination inhaler containing fluticasone, a potent inhaled corticosteroid (ICS), and formoterol, a long-acting β-agonist (LABA) with rapid onset and sustained bronchodilator effect, has been approved for treatment of persistent asthma in patients ≥12 years of age requiring combination ICS-LABA therapy.
David, Price, Elizabeth V, Hillyer
openaire   +2 more sources

Fluticasone Propionate/Formoterol Fumarate: A Review of Its Use in Persistent Asthma

Drugs, 2013
The corticosteroid fluticasone propionate (fluticasone) and the long-acting β₂-adrenoceptor agonist formoterol fumarate (formoterol) have been combined in a single, pressurized, metered-dose, aerosol inhaler for the maintenance treatment of patients aged ≥12 years with persistent asthma.
openaire   +2 more sources

Inhaled beclometasone dipropionate/formoterol fumarate extrafine fixed combination for the treatment of asthma

Expert Review of Respiratory Medicine, 2016
Inhaled therapy is often considered the cornerstone of asthma management and international guidelines recommend combination therapy of inhaled corticosteroids (ICS) and long-acting-beta2-agonists (LABA) in a large proportion of asthmatic patients. The effectiveness of ICS/LABA is dependent on the correct choice of device and proper inhalation technique,
CRISAFULLI, Ernesto   +6 more
openaire   +3 more sources

Disposition and metabolism of formoterol fumarate, a new bronchodilator, in rats and dogs

Xenobiotica, 1982
1. The disposition and metabolism of formoterol fumarate, a highly potent beta 2-adrenoceptor stimulant, were studied in rats and dogs. 2. After oral administration of [3H] formoterol fumarate to dogs, unchanged formoterol accounted for greater than 60% of the plasma radioactivity immediately after dosage; greater than 20% was due to the unchanged drug
H, Sasaki   +5 more
openaire   +2 more sources

Pharmacokinetics and effects of formoterol fumarate in healthy human subjects after oral dosing

European Journal of Clinical Pharmacology, 1998
To evaluate the effects of formoterol after oral administration on plasma eosinophils and plasma potassium in healthy subjects.Plasma concentrations of formoterol, peripheral eosinophil count and plasma potassium were determined during 7 h after oral administration of 168 microg of formoterol to eight healthy subjects. Descriptions of the concentration-
B T, van den Berg   +2 more
openaire   +2 more sources

Assessment of Critical Quality Attributes of Budesonide and Formoterol Fumarate Dihydrate in Dry Powder Inhalers Marketed in Pakistan

Journal of the Chemical Society of Pakistan
Dry powder inhalers (DPIs) have been well established and recognized for the delivery to the lungs. It provides better drug stability, less irritable, easy to use with deep penetration of drugs in the lungs.
Affan Ali Affan Ali   +2 more
semanticscholar   +1 more source

Formoterol fumarate.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2002
openaire   +3 more sources

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