Results 61 to 70 of about 1,735,900 (297)

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Long-Period Fiber Grating Within D-Shaped Fiber Using Magnetic Fluid for Magnetic-Field Detection

IEEE Photonics Journal, 2012
A magnetic sensor utilizing long-period fiber grating (LPFG) written by high frequency CO2 laser pulses in a D-shaped fiber and the magneto-optical effect of magnetic fluid is proposed.
Lei Gao, Tao Zhu, Ming Deng, Kin Seng Chiang, Xiaokang Sun, Xiaopeng Dong, Yusong Hou   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

1-Tb/s WDM-OFDM-PON System With Subband Access Scheme and Flexible Subcarrier-Level Bandwidth Allocation

IEEE Photonics Journal, 2013
A novel subband access scheme for multiband high-speed orthogonal frequency division multiplexing (OFDM) passive optical network (PON) is proposed, where the granularity of the bandwidth allocation is as small as the bandwidth of just one subcarrier and ...
Cheng Lei, Minghua Chen, Hongwei Chen, Sigang Yang, Ying Yu, Shizhong Xie   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Graphene-Based Saturable Absorber for Single-Longitudinal-Mode Operation of Highly Doped Erbium-Doped Fiber Laser

IEEE Photonics Journal, 2012
In this paper, a conventional wavelength band (C-band) fiber laser with a tunable single-longitudinal-mode (SLM) output using multilayer graphene as a saturable absorber is demonstrated. The proposed fiber laser uses a short length of highly doped erbium-
F. D. Muhammad, M. Z. Zulkifli, A. A. Latif, S. W. Harun, H. Ahmad   +4 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

TWDM-PON With Signal Remodulation and Rayleigh Noise Circumvention for NG-PON2

IEEE Photonics Journal, 2013
We propose and demonstrate a 40-Gb/s (4 × 10 Gb/s) downstream and 10-Gb/s (4 × 2.5 Gb/s) upstream time-wavelength-division-multiplexed passive optical network (TWDM-PON) using signal remodulation. Here, a downstream differential-phase-shift-
C. W. Chow, C. H. Yeh, K. Xu, J. Y. Sung, H. K. Tsang   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Study of Coupling Length of Concentrically Curved Waveguides

IEEE Photonics Journal, 2012
In this paper, we propose a method based on Helmholtz equation to determine the coupling length of the light propagating in concentrically curved waveguides by the conformal transformation.
Dong-Po Cai, Chii-Chang Chen, Chien-Chieh Lee, Tsong-Dong Wang   +3 more
doaj   +1 more source