Results 181 to 190 of about 2,429,415 (389)

Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA

Advanced Science, EarlyView.
We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang, Yunyun An, Mengqi Yang, Yuqi Pan, Xiaoyi Liu, Fanglei Gong, Huizhen Lin, Bianbian Tang, Yunxia Bai, Xin Zhao, Yu Zhao, Changzheng Du, Kun Sun   +12 more
wiley   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Growth Performance of Scalloped Spiny Lobster <i>Panulirus homarus</i> (Linaeus) Fed Formulated Diet in Recirculating System [PDF]

, 2022
Minh Le Hoang Duy, Luu Thi Tran
openalex   +1 more source

Formulated diet alters gut microbiota compositions in marine fishNibea coiborandNibea diacanthus

Aquaculture Research, 2018
Zhongzhen Li, Xinxu Zhang, J. Aweya, Shuqi Wang, Zhongyao Hu, Shengkang Li, X. Wen   +6 more
semanticscholar   +1 more source

The Microbiota Shapes Central Nervous System Myelination in Early Life

Advanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch, Emily G. Knox, Daniel Soong, Thomaz F. S. Bastiaanssen, Kalevi Trontti, Gabriel S. S. Tofani, Sophia Ivaschuk, Michael K. Collins, Donia Arafa, Jatin Nagpal, Iiris Hovatta, David A. Lyons, Gerard Clarke, John F. Cryan   +13 more
wiley   +1 more source

Responses of Semi-Scavenging F1 Crossbred (Rhode Island Red Male * Fayoumi Female) Grower, Pre-Layer Chickens to Diets of Different Nutrient Density Formulated with Locally Available Feed Ingredients

, 2007
Manotosh Dhar, S. D. Chowdhury, Md. Aslam Ali, Md. Jasimuddin Khan, M. A. H. Pramanik   +4 more
openalex   +2 more sources

The Intestinal Evacuation and Maximum Daily Consumption of Purified Formulated Diets by Juvenile Grass Carp (Ctenopharyngodon idella) [PDF]

, 2009
Zhen‐Yu Du, Lixia Tian, Gui‐Ying Liang, Han‐Bing Lan, Yongjian Liu   +4 more
openalex   +1 more source

Utilization of fish waste as fish meal substitute in formulated fish diet on thegrowth performance of Nile tilapia fish fry (Oreochromis niloticus)

, 2021
Anizah M.R., Sharifah Raina Manaf, Hilaliyah M.J.N.   +2 more
openalex   +1 more source

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source