Results 131 to 140 of about 1,177,031 (317)

Development of a Mucoadhesive In Situ Gelling Formulation for the Delivery of Lactobacillus gasseri into Vaginal Cavity

, 2019
Local administration of vaginal probiotics, especially lactobacilli, has been recently proposed as an effective prevention strategy against candidosis recurrences, which affect 40–50% of women.
Maria Cristina Bonferoni, Silvia Rossi, Pietro Grisoli, Franca Ferrari, Giuseppina Sandri, Barbara Vigani, Angela Faccendini   +6 more
core   +1 more source

Combination Hyaluronic Acid and Multipotent Stromal Cells Fails to Improve Rat Knee OA Outcomes Compared to Cells Alone

Orthopedic Research and Reviews
Kennedy Michele Davis,1 Megan Hamilton,2 Donald Muathe,2 Aldyn Wildey,2 Stephen Harrington,2 Douglas C Bittel,1 Michael Filla,1 Lisa Stehno-Bittel2,3 1College of Biosciences, Kansas City University, Kansas City, MO, USA; 2Likarda, Inc, Kansas City, MO ...
Davis KM, Hamilton M, Muathe D, Wildey A, Harrington S, Bittel DC, Filla M, Stehno-Bittel L   +7 more
doaj  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Metronidazole Suspension for Paediatric Use in Developing Countries: Formulation, Quality, and Stability

Background/Objectives. The paediatric population is a heterogenous group that is known to be a therapeutic orphan despite the recent incentives to promote the development of children’s formulations.
Chiara Zingarelli, Federica Fanton, Paola Brusa, Editson Lamy, Francesca Baratta, Gaetano Di Lascio   +5 more
core   +1 more source

Evaluating the Compatibility of New Recombinant Protein Antigens (Trivalent NRRV) with a Mock Pentavalent Combination Vaccine Containing Whole-Cell Pertussis: Analytical and Formulation Challenges

Vaccines
Introducing new recombinant protein antigens to existing pediatric combination vaccines is important in improving coverage and affordability, especially in low- and middle-income countries (LMICs).
Prashant Kumar, David A. Holland, Kathryn Secrist, Poorva Taskar, Brandy Dotson, Soraia Saleh-Birdjandi, Yetunde Adewunmi, Jennifer Doering, Nicholas J. Mantis, David B. Volkin, Sangeeta B. Joshi   +10 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

A new continuum based non-linear finite element formulation for modeling of dynamic response of deep water riser behavior

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The principal objective of this investigation is to develop a nonlinear continuum based finite element formulation to examine dynamic response of flexible ...
Hosseini Kordkheili, Seyed Ali
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

A Systematic Review of Clinical Case Formulation Methods and Pedagogies

DSW Capstone ReportThis systematic review aimed to improve behavioral health clinician training by examining different case formulation methods and pedagogical approaches.
Pearce, Jason
core  

Assessing Drug Product Shelf Life Using the Accelerated Stability Assessment Program: A Case Study of a GLPG4399 Capsule Formulation

Objective: To evaluate and project the shelf life of GLPG4399, an early-phase clinical drug formulation by applying the Accelerated Stability Assessment Program (ASAP) approach.
Sara Vrielynck, Kevin Roeleveld, Dattatray Modhave   +2 more
core   +1 more source