Results 111 to 120 of about 1,177,031 (317)

Tau-Targeted Therapeutic Strategies: Mechanistic Targets, Clinical Pipelines, and Analysis of Failures

Cells
Tau protein, a neuron-enriched microtubule-associated protein encoded by the MAPT gene, plays pivotal roles in microtubule stabilisation, axonal transport, and synaptic plasticity.
Xinai Shen, Huan Li, Beiyu Zhang, Yunan Li, Zheying Zhu   +4 more
doaj   +1 more source

Evaluation of combination product (Indoxacarb 5% + Fipronil 5% SC) against jassid, Amrasca biguttula biguttula and whitefly, Bemisia tabaci in cotton

The Indian Journal of Agricultural Sciences, 2015
Field studies were undertaken at research farm, IPFT, Gurgaon to evaluate the efficacy of indoxacarb 5% + fipronil 5% SC at four doses, viz. 100 (50+50) g a.i./ha ,125 (62.5+62.5) g a.i./ha, 150 (75+75) g a.i./ha and 250 (125+125) g a.i./ha, along with ...
D R BAJYA, M RANJITH, M C LAKHARAN
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Dry powder inhaler formulation of Lactobacillus rhamnosus GG targeting Pseudomonas aeruginosa infection in bronchiectasis maintenance therapy

The inhaled delivery of lactic acid bacteria (LAB) probiotics has been demonstrated to exert therapeutic benefits to the lungs due to LAB's immunomodulatory activities.
Hadinoto, Kunn, Wean Sin Cheow, Siyu Pu, Cheow, Wean Sin, Kunn Hadinoto, Jin-Won Park, Park, Jin-Won, The-Thien Tran, Tran, The-Thien, Pu, Siyu   +9 more
core   +1 more source

PROPERMAB: an integrative framework for in silico prediction of antibody developability using machine learning

mAbs
Selection of lead therapeutic molecules is often driven predominantly by pharmacological efficacy and safety. Candidate developability, such as biophysical properties that affect the formulation of the molecule into a product, is usually evaluated only ...
Bian Li, Shukun Luo, Wenhua Wang, Jiahui Xu, Dingjiang Liu, Mohammed Shameem, John Mattila, Matthew C. Franklin, Peter G. Hawkins, Gurinder S. Atwal   +9 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Handbook of Policy Formulation

Policy formulation relies upon the interplay of knowledge-based analysis of issues with power-based considerations, such as the political assessment of the costs and benefits of proposed actions, and its effects on the partisan and electoral concerns of ...
Howlett, Michael., Mukherjee, Ishani.
core  

Biologics as Therapeutical Agents Under Perspective Clinical Studies for Alzheimer’s Disease

Molecules
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterised by cognitive decline, synaptic loss, and multifaceted pathology involving amyloid-β (Aβ) aggregation, tau hyperphosphorylation, neuroinflammation, and impaired ...
Huan Li, Xinai Shen, Beiyu Zhang, Zheying Zhu   +3 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Formulation of Recombinant Therapeutic Proteins: Technological Innovation, Regulations, and Evolution Towards Buffer-Free Formulations

Background/Objectives: Formulating recombinant therapeutic proteins is essential to ensure their safety, efficacy, and stability. A growing trend in biopharmaceutical development is the move toward buffer-free formulations, which aim to reduce ...
Tomas Gabriel Bas
core   +1 more source