Results 101 to 110 of about 1,177,031 (317)
Formulating update messages [PDF]
ACM SIGPLAN Notices, 1995 This paper presents a method with which we can generate update messages for use with Smalltalk's dependency mechanism. The basic idea is that any messages which cause an object to change are forwarded to the object's dependants. The method is perfectly general and future-proofs objects against changes in their dependants.
openaire +1 more source
, 2020 The aim of this work was to assess the impact of an excipient in a pharmaceutical formulation containing candesartan cilexetil over the decomposition of the active pharmaceutical ingredient and to comparatively investigate the kinetics of degradation ...
Bianca Baul +10 more
core +1 more source
An Imine-Based Two-Dimensional Covalent Organic Framework for Gemcitabine Delivery
Colloids and InterfacesA 2D imine-linked covalent organic framework (COF) with good biocompatibility was synthesized using o-Dianisidine and 1,3,5-Triformylbenzene. The synthesized COF was characterized by using the Fourier transform infrared (FTIR), thermogravimetry analysis (
Kajal Kaliya +3 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Non-degenerate umbilics, the path formulation and gradient bifurcation problems
, 2004 Parametrised contact-equivalence is successful for the understanding and classification of the qualitative local behaviour of bifurcation diagrams and their perturbations. Path formulation is an alternative point of view.
Sitta, AM +3 more
core
Development of an inhalational formulation of Coenzyme Q₁₀ to treat lung malignancies [PDF]
, 2013 textCancer is the second leading cause of death in the United States and its onset is highly incident in the lungs, with very low long-term survival rates.
Carvalho, Thiago Cardoso
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
, 2018 In English.Includes bibliographical references and index.Annotation. Volume 3 of Formulation Science and Technology is a survey of the applications of formulations in a variety of fields, based on the theories presented in Volumes 1 and 2.
Tadros Tharwat F.,
core
Objectives: The development of novel long-acting injectables for local anesthetics is necessary to effectively manage the acute postoperative pain. The aim of this study was to prepare an injectable oil-based formulation of ropivacaine (ROP) prodrug ...
Ruihan Zhao +8 more
core +1 more source