Results 81 to 90 of about 1,464,537 (295)
An Imine-Based Two-Dimensional Covalent Organic Framework for Gemcitabine Delivery
Colloids and InterfacesA 2D imine-linked covalent organic framework (COF) with good biocompatibility was synthesized using o-Dianisidine and 1,3,5-Triformylbenzene. The synthesized COF was characterized by using the Fourier transform infrared (FTIR), thermogravimetry analysis (
Kajal Kaliya +3 more
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Problem-formulation in a South African organization. Executive summary [PDF]
Complex Problem Solving is an area of cognitive science that has received a good amount of attention, but theories in the field have not progressed accordingly.
Roberts, Paul A. B., Carlo, Les
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
CellsTau protein, a neuron-enriched microtubule-associated protein encoded by the MAPT gene, plays pivotal roles in microtubule stabilisation, axonal transport, and synaptic plasticity.
Xinai Shen +4 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Scientific ReportsOilseed Brassica, an important edible oilseed crop of the world, is facing severe threat from the parasitic weed ‘Egyptian broomrape’ [Phelipanche aegyptiaca (Pers.) Pomel] with yield penalty of 0-100%.
R. S. Jat +6 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Handbook of Policy Formulation
Policy formulation relies upon the interplay of knowledge-based analysis of issues with power-based considerations, such as the political assessment of the costs and benefits of proposed actions, and its effects on the partisan and electoral concerns of ...
Howlett, Michael., Mukherjee, Ishani.
core
mAbsSelection of lead therapeutic molecules is often driven predominantly by pharmacological efficacy and safety. Candidate developability, such as biophysical properties that affect the formulation of the molecule into a product, is usually evaluated only ...
Bian Li +9 more
doaj +1 more source