Results 181 to 190 of about 316,859 (287)

Lysine Oxidation by LOXL2 in Single Strands Versus Triple Helices: Implications for Collagen‐Related Diseases

Angewandte Chemie, EarlyView.
The oxidation of Lys residues in proline‐rich single‐stranded collagen by LOXL2, a key enzyme for tissue maturation and linked to diseases, was revealed. Oxidation occurs at rates comparable to or higher than those of Lys in unstructured telopeptides, the well‐known native sites of Lysyl oxidase (LOX) activity.
Laura M. Poller, Tomas Fiala, Helma Wennemers   +2 more
wiley   +1 more source

[The progress of participation research. A sociological analysis of its institutionalization]. [PDF]

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
Schäfers M, Wansing G.
europepmc   +1 more source

Rational Molecular Design to Improve Digital Polymer Readout in Aerolysin‐Based Nanopore Sequencing

Angewandte Chemie, EarlyView.
Nanopore sensing holds significant yet underexplored potential for decoding synthetic digital polymers. In this study, we synthesized an extensive library of sequence‐defined poly(phosphodiester)s and evaluated their performance in aerolysin‐based sequencing. By systematically optimizing molecular parameters, we identified an ideal combination of coded
Zhaozheng Yang, Juan Francisco Bada Juarez, Georgette Obeid, Alissa Agerova, Thomas R. Bryner, Davide Cois, Maria J. Marcaida, Chan Cao, Matteo Dal Peraro, Jean‐François Lutz   +9 more
wiley   +1 more source

Inherent α-Helix Around Tyrosine 183 in the Intrinsically Disordered Tail of the Multi-Site Docking Platform Gab1. [PDF]

Biopolymers
Dietrich A, Lewitzky M, Gruber T, Balbach J, Feller SM, Weininger U.   +5 more
europepmc   +1 more source

Modifications of Lysine Residues 294 and 311 Within the Microtubule‐Binding Region Alter Tau Aggregation and Tubulin Binding Equilibria

Angewandte Chemie, EarlyView.
The molecular consequences of specific lysine modifications in Alzheimer´s disease remain insufficiently resolved in the context of full‐length protein. Here we integrate protein semisynthesis, segmental isotope labelling, and high‐resolution NMR spectroscopy to achieve residue‐resolved interrogation of site‐specific acetylation and carboxymethylation.
Dominik P. Vogl, Mario Migotti, Robert Konrat, Anne C. Conibear, Christian F. W. Becker   +4 more
wiley   +1 more source

Genome-wide SNP-based genomic diversity and population structure analysis in alpaca populations from Europe and Peru. [PDF]

G3 (Bethesda)
Tan K, Adeniyi OO, Letko A, Manz E, Wagner HW, Zanolari P, More M, Gutierrez-Reynoso GA, Drögemüller C, Lühken G.   +9 more
europepmc   +1 more source

Unerwartet starke elektrostatische Abschirmung in Nano‐Ionen‐Lösungen

Angewandte Chemie, EarlyView.
Messungen mittels Kolloidsonden‐Rasterkraftmikroskopie offenbaren eine unerwartet starke elektrostatische Abschirmung in wässrigen Lösungen der beiden Polyoxometallate Wolframatophosphorsäure [PW12O40]3−${[{\rm PW}_{12}{\rm O} _{40}]}^{3-}$ und Wolframatokieselsäure [SiW12O40]4−${[{\rm SiW}_{12}{\rm O} _{40}]}^{4-}$.
Thomas Tilger, Esther Ohnesorge, Hayden Robertson, Michael Ludwig, Michalis Tsintsaris, Regine von Klitzing   +5 more
wiley   +1 more source

Traces of Parenthood but Not Pregnancy Loss in UK Biobank Structural Brain MRI Data. [PDF]

Hum Brain Mapp
Fischer JL, Skalkidou A, Derntl B, Kaufmann T.   +3 more
europepmc   +1 more source

Noncanonical Peloruside A Biosynthesis by an Uncultivated Verrucomicrobiota Symbiont

Angewandte Chemie, EarlyView.
Noncanonical biochemistry of the peloruside PKS characterized in this work, comprising double bond generation by a noncanonical tridomain (blue), acetyl‐CoA recycling (orange), and proofreading systems (purple and yellow). The Z‐double bond is installed by TEB1 through O‐acetylation and acetate elimination. The acyl ligase PelB (AL, orange) selectively
Amy E. Fraley, Michael Rust, Moritz Wagner, Ida R. Hipfinger, Paul J. N. Böhm, Cora L. Dieterich, Christopher M. Field, Michael J. Page, Jeremy G. Owen, Robert A. Keyzers, Shinichi Sunagawa, Jörn Piel   +11 more
wiley   +1 more source

Vibration promotes catabolic activity in degenerated bovine intervertebral discs despite estrogen supplementation

Brain and Spine
G.Q. Teixeira, F. Figel, J.U. Jansen, M. Ahrens, F. Widmayer, H.J. Wilke, A. Ignatius, M. Haffner-Luntzer, C. Neidlinger-Wilke   +8 more
doaj   +1 more source