Results 31 to 40 of about 594,136 (249)

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Digital Innovations and Technological Sovereignty

Wirtschaftsdienst, 2020
Digital innovations are changing our economies and societies. Shaping this transformation in line with core societal values and in a continual exchange with society is a key political challenge.
Ina Schieferdecker, Christoph March
doaj   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

Manufacturing Continuous Fiber‐Reinforced Printing Filaments: Development of a Post‐Consolidation Unit

Advanced Engineering Materials, EarlyView.
A novel, temperature‐controlled post‐consolidation unit is developed to test its potential to improve the melt impregnation process used to manufacture continuous fiber‐reinforced filaments for additive manufacturing of high‐performance thermoplastics.
Daniel Beermann, Patrick Schiebel, David May   +2 more
wiley   +1 more source

Two-dimensional contour decomposition: Decomposing mortality differences into initial difference and trend components by age and cause of death [PDF]

Demographic Research
BACKGROUND: Conventional decomposition analysis identifies contributions from differences in covariates in total between-population difference, but does not address the question of the historical roots of the differences.
Dmitri A. Jdanov, Domantas Jasilionis, Vladimir Shkolnikov   +2 more
doaj   +1 more source

Siedlungswasserwirtschaft im Zeitalter der Digitalisierung

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2020
Die Digitalisierung in der Siedlungswasserwirtschaft kann dazu beitragen, die Aufgaben, die sich für Wasserversorgung und Abwasserbeseitigung aufgrund des demografischen und klimatischen Wandels ergeben, besser anzugehen.
Martin Zimmermann, Engelbert Schramm, Björn Ebert   +2 more
doaj   +1 more source

Dynamic Testing of Cold Gas Sprayed Bipolar Plates–Porous Transport Layer Coating System in Proton Exchange Membrane Water Electrolysis

Advanced Engineering Materials, EarlyView.
Through direct application of porous transport layer (PTL) on the bipolar plate (BPP) with thermal spraying, the interfacial contact resistance is improved. With the cold gas sprayed BPP–PTL coating system, a proton exchange membrane water electrolysis cell with a cell voltage of Ucell = 1.9 V can be operated up to i = 2.5 A/cm2 in a dynamic mode ...
Kirsten Bobzin, Marvin Erck, Kevin Jasutyn, Katja Radermacher, Andreas Bund, Mario Kurniawan   +5 more
wiley   +1 more source

Multi-wavelength anomalous diffraction de novo phasing using a two-colour X-ray free-electron laser with wide tunability

Nature Communications, 2017
X-ray free-electron lasers produce bright femtosecond X-ray pulses. Here, the authors use a two-colour X-ray free-electron laser beam for simultaneous two-wavelength data collection and show that protein structures can be determined with multiple ...
Alexander Gorel, Koji Motomura, Hironobu Fukuzawa, R. Bruce Doak, Marie Luise Grünbein, Mario Hilpert, Ichiro Inoue, Marco Kloos, Gabriela Kovácsová, Eriko Nango, Karol Nass, Christopher M. Roome, Robert L. Shoeman, Rie Tanaka, Kensuke Tono, Yasumasa Joti, Makina Yabashi, So Iwata, Lutz Foucar, Kiyoshi Ueda, Thomas R. M. Barends, Ilme Schlichting   +21 more
doaj   +1 more source

A unified framework of demographic time

Genus, 2017
Demographic thought and practice is largely conditioned by the Lexis diagram, a two-dimensional graphical representation of the identity between age, period, and birth cohort.
Tim Riffe, Jonas Schöley, Francisco Villavicencio   +2 more
doaj   +1 more source

Resistance Rapid Heating of Aluminum Coatings in an Extreme High Vacuum–Adequate Atmosphere for Hot Stamping

Advanced Engineering Materials, EarlyView.
The subject of this work is the development of a corrosion‐protective coating on steel sheets for form hardening. Rapid heating in an extreme high vacuum (XHV)‐adequate atmosphere is a useful method to prevent oxidation during alloying of 22MnB5 and aluminum to obtain a metallurgical bonding.
Lorenz Albracht, Alexander Schnettger, Ulrich Holländer, Sven Hübner, Bernd‐Arno Behrens, Hans Jürgen Maier   +5 more
wiley   +1 more source