Results 51 to 60 of about 1,679,670 (240)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

How Firms Can Hedge Against Market Risk

Studies in Logic, Grammar and Rhetoric, 2014
The article presents a problem of proper hedging strategy in expected utility model when forward contracts and options strategies are available. We consider a case of hedging when an investor formulates his own expectation on future price of underlying ...
Echaust Krzysztof
doaj   +1 more source

Special Editor’s Note

Journal of Transnational American Studies, 2012
Special Editor’s Note for JTAS 4.1’s ...
Thomas Bender
doaj   +1 more source

Forward Editor’s Note

Journal of Transnational American Studies, 2012
Forward Editor’s Note for JTAS 4 ...
Greg Robinson
doaj   +3 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Wpływ wejścia w życie MiFID II na ryzyko funkcjonowania spółek energetycznych w Polsce [PDF]

internetowy Kwartalnik Antymonopolowy i Regulacyjny, 2019
Wprowadzenie regulacji MiFID II wymagało implementacji tej dyrektywy do krajowego porządku prawnego z uwzględnieniem pewnej odrębności regulacji krajowych. Niestety do implementacji nie doszło przed wejściem w życie dyrektywy.
Paweł Hawranek, Dariusz Michalski, Daniel Borkowski   +2 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The paradox of policy competition: A simple post-Keynesian theory of how beggar-thy-neighbour FDI-led growth strategies work in principle but not in practice

PSL Quarterly Review
In recent decades, governments around the world have increasingly used various forms of state aid to try to attract and retain the business activity of foreign-owned multinational corporations.
Ryan Woodgate
doaj   +1 more source

Foreword

Internet Archaeology, 2007
There is rather a special flavour to research into the Mesolithic period. Immersing ourselves in the study of dynamic, mobile communities facing ever changing environments, with interpretations resting on sparse, rather unimpressive evidence brings a ...
Penny Spikins
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source