Results 81 to 90 of about 40,199 (294)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Potential field based navigation for planetary rovers using internal states [PDF]

, 2008
The work in this paper aims to introduce analysis and applications for the internal state model which is a new model for a swarm of rovers interacting via pair-wise attractive and repulsive potentials.
Abdel Wahid, Mohamed Hussien Mabrouk, McInnes, C.R.   +1 more
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Aplikasi Deteksi Dini Defisiensi Mineral Mikro pada Manusia Berbasis Web

IJCCS (Indonesian Journal of Computing and Cybernetics Systems), 2014
Abstrak Kekurangan gizi menjadi salah satu masalah yang dialami oleh masyarakat Indonesia, khususnya defisiensi mineral mikro. Pada dasarnya hal ini dikarenakan kurangnya pemahaman masyarakat akan pentingnya pola konsumsi makanan seimbang serta ...
Nina Sevani, Rheinhard Unwaru, Rheinhard Unwaru   +2 more
doaj   +1 more source

Aplikasi Sistem Pendukung Keputusan Diagnosa Penyakit Paru-paru Dengan Metode Forward Chaining [PDF]

, 2011
In Indonesian lung disease have a high death. Tubercolosis (TB) world report (2006) by World Health Organization (WHO), Indonesia still the third biggest after India and China with around 539.000 cases and around 101.000 peoples die for a year.
Setyowibowo, S. (Sigit), Yunus, M. (Mahmud)   +1 more
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Sistem Deteksi Dini Jenis Perilaku Attention Deficit Hyperactivity Disorder Berdasarkan Diasnogtic and Statistical Manual of Mental Disoders

Jurnal informatika UPGRIS, 2018
The ADHD  is a hyperactive individual and tends to respond excessively. In identification, the therapist only observes the child's development. The results of the therapist's observation will show that the child has ADHD Collection of characteristics ...
Fajar - Suryani, Ardymulya Iswardani
doaj   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source