Results 111 to 120 of about 1,336,459 (329)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Forward Modeling of Two-Dimensional Nuclear Magnetic Resonance Logging Responses

Cejing jishu
To reveal the response mechanisms of two-dimensional nuclear magnetic resonance (NMR) logging, establish a reliable interpretation basis, and address the challenges of accurate fluid identification and quantitative evaluation in complex heterogeneous ...
ZHANG Xinyu, LUO Sihui, XIAO Lizhi, LIAO Guangzhi   +3 more
doaj   +1 more source

Hybrid mesh for magnetotelluric forward modeling based on the finite element method. [PDF]

Sci Rep, 2023
Yu N, Wu X, Liu X, Li R, Zhang H, Gao L.
europepmc   +1 more source

3D forward modeling and analysis of a long‐offset transient electromagnetic method for an arbitrarily anisotropy earth [PDF]

, 2019
Yajun Liu, Bü lent Tezkan, Xiangyun Hu, Pritam Yogeshwar   +3 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Two-Step Forward Modeling for GPR Data of Metal Pipes Based on Image Translation and Style Transfer

Remote Sensing
Ground-penetrating radar (GPR) is an important geophysical technique in subsurface detection. However, traditional numerical simulation methods such as finite-difference time-domain (FDTD) face challenges in accurately simulating complex heterogeneous ...
Zhishun Guo, Yesheng Gao, Zicheng Huang, Mengyang Shi, Xingzhao Liu   +4 more
doaj   +1 more source

EMI: Exploration with Mutual Information

, 2019
Reinforcement learning algorithms struggle when the reward signal is very sparse. In these cases, naive random exploration methods essentially rely on a random walk to stumble onto a rewarding state. Recent works utilize intrinsic motivation to guide the
Jeong, Yeonwoo, Kim, Hyoungseok, Kim, Jaekyeom, Levine, Sergey, Song, Hyun Oh   +4 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Multi‐Input Multi‐Output Modeling of Anthill Clay‐Bonded Sand Mold System Using Artificial Neural Networks: Forward and Reverse Predictions

Engineering Reports
Anthill clay sand molding is characterized as a multi‐input, multi‐output system where molding sand properties, such as permeability, compression strength, collapsibility, and mold hardness, are affected by an array of process parameters, including ...
N. Prasad Chandran, G. C. Manjunath Patel, Ganesh R. Chate, Oguzhan Der, Chithirai Pon Selvan   +4 more
doaj   +1 more source

Regression analysis on forward modeling of diffuse optical tomography system for carcinoma cell detection. [PDF]

Sci Rep, 2023
Maheswari KU, Thilak M, SenthilKumar N, Nagaprasad N, Jule LT, Seenivasan V, Ramaswamy K.   +6 more
europepmc   +1 more source