Results 91 to 100 of about 3,775,212 (302)

Optimal hedging in European electricity forward markets. [PDF]

open access: yes
This article is concerned with modeling the dynamic and distributional properties of daily spot and forward electricity prices across European wholesale markets. Prices for forward contracts are extracted from a unique database from a major energy trader
Sévi, Yannick, Le Pen, Yannick
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

A semiparametric factor model for electricity forward curve dynamics [PDF]

open access: yes
In this paper we introduce the dynamic semiparametric factor model (DSFM) for electricity forward curves. The biggest advantage of our approach is that it not only leads to smooth, seasonal forward curves extracted from exchange traded futures and ...
Weron, Rafal, Borak, Szymon
core  

Accounting for imperfect forward modeling in geophysical inverse problems — Exemplified for crosshole tomography [PDF]

open access: yes, 2014
Inversion of geophysical data relies on knowledge about how to solve the forward problem, that is, computing data from a given set of model parameters. In many applications of inverse problems, the solution to the forward problem is assumed to be known ...
Holm Jacobsen, Bo   +3 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Learning Forward Models for Robots.

open access: yes, 2005
Forward models enable a robot to predict the effects of its actions on its own motor system and its environment. This is a vital aspect of intelligent behaviour, as the robot can use predictions to decide the best set of actions to achieve a goal.
Dearden,A., Demiris,Y.K.
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Forward Modeling for the Fine Detection of Geological Abnormal Area in Coal Seams Using High-frequency Radio Imaging Method

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The radio imaging method (RIM) can be used in underground mines to identify geologically hazardous areas; however, it does not yield accurate results. To address this issue, a high-frequency (1–8 MHz) RIM is proposed here for the fine detection of
Shun Yang   +3 more
doaj   +1 more source

The Propensity for Density in Feed-Forward Models

open access: yes
Does the process of training a neural network to solve a task tend to use all of the available weights even when the task could be solved with fewer weights? To address this question we study the effects of pruning fully connected, convolutional and residual models while varying their widths.
Nandi Schoots   +4 more
openaire   +3 more sources

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