Results 91 to 100 of about 264,379 (313)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

The Propensity for Density in Feed-Forward Models

Does the process of training a neural network to solve a task tend to use all of the available weights even when the task could be solved with fewer weights? To address this question we study the effects of pruning fully connected, convolutional and residual models while varying their widths.
Nandi Schoots, Alex Jackson, Ali Kholmovia, Peter McBurney, Murray Shanahan   +4 more
openaire   +2 more sources

Dimensionality Reduction and Uncertainty Quantification for Inverse Problems

, 2015
Many inverse problems in science and engineering involve multi-experiment data and thus require a large number of forward simulations. Dimensionality reduction techniques aim at reducing the number of forward solves by (randomly) subsampling the data. In
van Leeuwen, Tristan, Mathematical Modeling, Sub Mathematical Modeling   +2 more
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Improved Estimates of Sub‐Regional Groundwater Storage Anomaly Using Coordinated Forward Modeling

Water Resources Research
Groundwater storage anomaly (GWSA) can be estimated either at the large scale from the Gravity Recovery and Climate Experiment (GRACE) or at the local scale based on in situ observed groundwater level (GWL) and aquifer storage parameters.
Yalin Ma, Yun Pan, Chong Zhang, Pat J.‐F. Yeh, Li Xu, Zhiyong Huang, Huili Gong   +6 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Forward modeling of spectral gamma-ray (SGR) logging in sedimentary formations

Geofísica Internacional
We propose a new approach to improve spectral gamma-ray (SGR) logging forward modeling by considering the radioactive minerals present in the rock as gamma-ray sources. This is based on the radioactive attenuation theory. The assumptions are: 1) minerals
Francisco Miguel Lechuga Lagos, Ambrosio Aquino López, Miguel Ángel Valdez Grijalva, José Oscar Campos Enríquez   +3 more
doaj   +1 more source

Forward Modeling of a Pseudostreamer

The Astrophysical Journal, 2019
Abstract In this paper, we present an analysis of a pseudostreamer embedding a filament cavity, observed on 2015 April 18 on the solar southwest limb. We use the flux-rope insertion method to construct nonlinear force-free field (NLFFF) models constrained by observed Solar Dynamics Observatory (SDO)/AIA coronal structures and the SDO ...
Nishu Karna, Antonia Savcheva, Kévin Dalmasse, Sarah Gibson, Svetlin Tassev, Giuliana de Toma, Edward E. DeLuca   +6 more
openaire   +2 more sources

Optimal hedging in European electricity forward markets. [PDF]

This article is concerned with modeling the dynamic and distributional properties of daily spot and forward electricity prices across European wholesale markets. Prices for forward contracts are extracted from a unique database from a major energy trader
Sévi, Yannick, Le Pen, Yannick
core