Results 71 to 80 of about 264,379 (313)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Response characteristics of ground-penetrating radar for subgrade void based on random reconstruction of soil-rock mixture

Yantu gongcheng xuebao
In order to study the response characteristics of geological radar waves to soil-rock mixed subgrade void, a microscopic model of soil-rock mixture with pores is built with considering the randomness and non-uniformity of soil-rock mixtures.
SHI Wenhao1, 2, 3 , WU Yifeng1, 3, ZHANG Yonghui3, ZHU Xiaodan3, FAN Lüye3, 4
doaj   +1 more source

Forward stability and model path selection

Statistics and Computing
AbstractMost scientific publications follow the familiar recipe of (i) obtain data, (ii) fit a model, and (iii) comment on the scientific relevance of the effects of particular covariates in that model. This approach, however, ignores the fact that there may exist a multitude of similarly-accurate models in which the implied effects of individual ...
Nicholas Kissel, Lucas Mentch
openaire   +2 more sources

An orthogonal forward regression technique for sparse kernel density estimation [PDF]

, 2008
Using the classical Parzen window (PW) estimate as the desired response, the kernel density estimation is formulated as a regression problem and the orthogonal forward regression technique is adopted to construct sparse kernel density (SKD) estimates ...
Harris, C. J., X. Hong, S. Chen, Chen, Sheng, Hong, X., C.J. Harris, Harris, Chris J., Chen, S.   +7 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Forward equations for option prices in semimartingale models [PDF]

We derive a forward partial integro-differential equation for prices of call options in a model where the dynamics of the underlying asset under the pricing measure is described by a -possibly discontinuous- semimartingale. This result generalizes Dupire'
Rama Cont, Amel Bentata
core   +2 more sources

Sensitivity Analysis of Leakage Correction of GRACE Data in Southwest China Using A-Priori Model Simulations: Inter-Comparison of Spherical Harmonics, Mass Concentration and In Situ Observations

Sensors, 2019
The Gravity Recovery and Climate Experiment (GRACE) level-2 spherical harmonic (SH) solutions are noisy and thus require filtering. Filtering reduces noise but affects signal quality via signal leakage.
Zhiyong Huang, Jiu Jimmy Jiao, Xin Luo, Yun Pan, Chong Zhang   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A Semi-Automatic Coupling Geophone for Tunnel Seismic Detection

Sensors, 2019
The tunnel seismic method allows for the detection of the geology in front of a tunnel face for the safety of tunnel construction. Conventional geophones have problems such as a narrow spectral width, low sensitivity, and poor coupling with the tunnel ...
Yao Wang, Nengyi Fu, Zhihong Fu, Xinglin Lu, Xian Liao, Haowen Wang, Shanqiang Qin   +6 more
doaj   +1 more source