Results 61 to 70 of about 264,379 (313)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Applied SciencesMine water inrush remains one of the major hazards threatening the safety of coal mining operations. To assess the feasibility of integrating transient electromagnetic (TEM) and direct-current (DC) methods for advanced detection in underground settings ...
Yunlan He +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Meitian dizhi yu kantanObjective and MethodDensely distributed sub-seismic faults have emerged as a major hidden disaster-causing geological factor, heavily influencing both the production efficiency and operational safety of coal mines. To achieve precise advance detection of
Haodang LI +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A cubed-sphere based method for global and regional modeling of the lithospheric magnetic field
Earth and Planetary PhysicsThe Earth’s magnetic field, which has been extensively observed from ground to satellite altitudes over several decades, originates from multiple sources, such as the core dynamo, the conductive mantle, the magnetized lithosphere, and the space current ...
Liang Yin +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
MathematicsWith the widespread application of the direct-current resistivity method, searching for accurate and fast-forward algorithms has become the focus of research for geophysicists and engineers.
Xiaozhong Tong, Ya Sun
doaj +1 more source
Magnetotelluric Deep Learning Forward Modeling and Its Application in Inversion
, 2023 Magnetotelluric (MT) inversion and forward modeling are closely linked. The optimization and iteration processes of the inverse algorithm require frequent calls to forward modeling.
Jian Hu +6 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source