Results 61 to 70 of about 1,333,112 (303)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Electromagnetic Response Characteristics and Applications of Numerical Simulation of Geoelectricity in Water-Rich Areas of Mines

Applied Sciences
Mine water inrush remains one of the major hazards threatening the safety of coal mining operations. To assess the feasibility of integrating transient electromagnetic (TEM) and direct-current (DC) methods for advanced detection in underground settings ...
Yunlan He, Kexin Li, Suping Peng, Xikai Wang, Zibo Tian, Lulu Fang   +5 more
doaj   +1 more source

Hiddleston’s Causal Modeling Semantics and the Distinction between Forward-Tracking and Backtracking Counterfactuals [PDF]

, 2017
Some cases show that counterfactual conditionals (‘counterfactuals’ for short) are inherently ambiguous, equivocating between forward-tracking and backtracking counterfactu- als.
Lee, Kok Yong
core  

Nonparametric estimation of the heterogeneity of a random medium using Compound Poisson Process modeling of wave multiple scattering

, 2009
In this paper, we present a nonparametric method to estimate the heterogeneity of a random medium from the angular distribution of intensity transmitted through a slab of random material.
Bihan, Nicolas Le, Margerin, Ludovic
core   +4 more sources

Traveltime and conversion-point computations and parameter estimation in layered, anisotropic media by tau-p transform [PDF]

, 2003
Anisotropy influences many aspects of seismic wave propagation and, therefore, has implications for conventional processing schemes. It also holds information about the nature of the medium.
Kendall, M.J., Van der Baan, M.
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Application of seismic-while-tunnelling detection in the identification of densely distributed sub-seismic faults

Meitian dizhi yu kantan
Objective and MethodDensely distributed sub-seismic faults have emerged as a major hidden disaster-causing geological factor, heavily influencing both the production efficiency and operational safety of coal mines. To achieve precise advance detection of
Haodang LI, Kang LI, Jian CHEN, Xiaozhong SONG, Dan JIN, Baoli WANG   +5 more
doaj   +1 more source

A Nonlinear Force-Free Magnetic Field Approximation Suitable for Fast Forward-Fitting to Coronal Loops. I. Theory

, 2012
We derive an analytical approximation of nonlinear force-free magnetic field solutions (NLFFF) that can efficiently be used for fast forward-fitting to solar magnetic data, constrained either by observed line-of-sight magnetograms and stereoscopically ...
A. Gary, A. Malanushenko, A. Malanushenko, A. Sandman, A.W. Sandman, B.C. Low, C.J. Schrijver, E.R. Priest, J.A. Klimchuk, J.D. Jackson, L. Feng, M.J. Aschwanden, M.J. Aschwanden, M.J. Aschwanden, M.J. Aschwanden, M.L. DeRosa, M.S. Wheatland, Markus J. Aschwanden, P. Ruan, P.A. Conlon, P.A. Sturrock, T. Gold, T. Török, T. Wiegelmann, T. Wiegelmann, T. Wiegelmann, T. Wiegelmann, T.J.M. Boyd, T.R. Metcalf   +28 more
core   +1 more source

First radial velocity results from the MINiature Exoplanet Radial Velocity Array (MINERVA) [PDF]

, 2019
The MINiature Exoplanet Radial Velocity Array (MINERVA) is a dedicated observatory of four 0.7m robotic telescopes fiber-fed to a KiwiSpec spectrograph. The MINERVA mission is to discover super-Earths in the habitable zones of nearby stars.
Baker, Ashley D., Barnes, Stuart I., Beatty, Thomas G., Berlind, Perry, Blackhurst, Eric, Blake, Cullen H., Bolton, Adam S., Bottom, Michael, Cale, Bryson, Calkins, Michael L., Colón, Ana, Cornachione, Matthew A., de Saintonge, Forest Chaput, de Vera, Jon, Eastman, Jason D., Esquerdo, Gilbert, Falco, Emilio E., Fortin, Pascal, Garcia-Mejia, Juliana, Geneser, Claire, Gibson, Steven R., Grell, Gabriel, Groner, Ted, Halverson, Samuel, Hamlin, John, Henderson, M., Horner, J., Houghton, Audrey, Janssens, Stefaan, Johnson, John Asher, Johnson, Samson A., Jonas, Graeme, Jones, Damien, Kirby, Annie, Lawrence, George, Luebbers, Julien Andrew, McCrady, Nate, Morton, Timothy D., Muirhead, Philip S., Myles, Justin, Nava, Chantanelle, Plavchan, Peter, Reed, Tony, Relles, Howard M., Riddle, Reed, Rivera-García, Kevin O, Robinson, Connor, Schap III, William J., Sergi, Anthony, Sliski, David H., Swift, Jonathan J., Wang, Sharon X., Wilson, Maurice L., Wittenmyer, Robert A., Wright, Jason T.   +54 more
core   +1 more source