Results 81 to 90 of about 1,333,112 (303)

Forward Modeling of Double Neutron Stars: Insights from Highly-Offset Short Gamma-Ray Bursts

, 2020
We present a detailed analysis of two well-localized, highly offset short gamma-ray bursts---GRB~070809 and GRB~090515---investigating the kinematic evolution of their progenitors from compact object formation until merger. Calibrating to observations of
Berry, Christopher P. L., Fong, Wen-fai, Kalogera, Vicky, Kelley, Luke Zoltan, Nugent, Anya, Zevin, Michael   +5 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Response characteristics of ground-penetrating radar for subgrade void based on random reconstruction of soil-rock mixture

Yantu gongcheng xuebao
In order to study the response characteristics of geological radar waves to soil-rock mixed subgrade void, a microscopic model of soil-rock mixture with pores is built with considering the randomness and non-uniformity of soil-rock mixtures.
SHI Wenhao1, 2, 3 , WU Yifeng1, 3, ZHANG Yonghui3, ZHU Xiaodan3, FAN Lüye3, 4
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Sensitivity Analysis of Leakage Correction of GRACE Data in Southwest China Using A-Priori Model Simulations: Inter-Comparison of Spherical Harmonics, Mass Concentration and In Situ Observations

Sensors, 2019
The Gravity Recovery and Climate Experiment (GRACE) level-2 spherical harmonic (SH) solutions are noisy and thus require filtering. Filtering reduces noise but affects signal quality via signal leakage.
Zhiyong Huang, Jiu Jimmy Jiao, Xin Luo, Yun Pan, Chong Zhang   +4 more
doaj   +1 more source

Forward modeling of emission in SDO/AIA passbands from dynamic 3D simulations

, 2017
It is typically assumed that emission in the passbands of the Atmospheric Imaging Assembly (AIA) onboard the Solar Dynamics Observatory (SDO) is dominated by single or several strong lines from ions that under equilibrium conditions are formed in a ...
Aschwanden, Bart De Pontieu, De Pontieu, Feldman, Feldman, Foster & Testa, Gudiksen, Hansteen, Hansteen, Hansteen, Heggland, Juan Martínez-Sykora, Martínez-Sykora, Martínez-Sykora, Martínez-Sykora, Martínez-Sykora, Martínez-Sykora, Paola Testa, Rouppe van der Voort, Schmelz, Testa, Viggo Hansteen   +21 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Semi-Automatic Coupling Geophone for Tunnel Seismic Detection

Sensors, 2019
The tunnel seismic method allows for the detection of the geology in front of a tunnel face for the safety of tunnel construction. Conventional geophones have problems such as a narrow spectral width, low sensitivity, and poor coupling with the tunnel ...
Yao Wang, Nengyi Fu, Zhihong Fu, Xinglin Lu, Xian Liao, Haowen Wang, Shanqiang Qin   +6 more
doaj   +1 more source

State maps for linear systems

, 1997
Modeling of physical systems consists of writing the equations describing a phenomenon and yields as a result a set of differential-algebraic equations.
Rapisarda, Paolo, Willems, Jan C.
core   +3 more sources