Results 41 to 50 of about 264,379 (313)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Remote Sensing, 2020 Terrestrial laser scanning is used in many disciplines of engineering. Examples include mobile mapping, architecture surveying, archaeology, as well as monitoring and surveillance measurements.
Ulrich Stenz +3 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Petrophysics Parameter Inversion and Its Application Based on the Transient Electromagnetic Method
Applied SciencesThe transient electromagnetic (TEM) method is a widely used geophysical technique for detecting subsurface electrical structures. However, its inversion results are typically limited to resistivity parameters, making it challenging to directly infer key ...
Xiaozhen Teng +5 more
doaj +1 more source
Earth and Planetary Physics, 2018 The Emeishan large igneous province (hereafter named by its acronym ELIP) is the first accepted large igneous region in China. The current study tries to reconstruct the density structure of the crust in this region.
Xi Zhang +5 more
doaj +1 more source
Influence of Sea Level Anomaly on Underwater Gravity Gradient Measurements
Sensors, 2022 Considering the theoretical research needs of gravity gradient detection and navigation, this study uses the right rectangular prism method to calculate the disturbing gravity gradient from sea level anomalies in the range of 5° × 5° in the Kuroshio ...
Pengfei Xian +3 more
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Noise Mitigation of the SMOS L1C Multi-Angle Brightness Temperature Based on the Lookup Table
Remote SensingOwing to the inherently lower sensitivity of microwave aperture synthesis radiometers (ASRs), Soil Moisture and Ocean Salinity (SMOS) satellite brightness temperature (TB) measurements exhibit significantly greater system noise than real-aperture ...
Ke Chen +4 more
doaj +1 more source
3D Airborne EM Forward Modeling Based on Time-Domain Spectral Element Method
Remote Sensing, 2021 Airborne electromagnetic (AEM) method uses aircraft as a carrier to tow EM instruments for geophysical survey. Because of its huge amount of data, the traditional AEM data inversions take one-dimensional (1D) models.
Changchun Yin +6 more
doaj +1 more source