Results 101 to 110 of about 29,895 (169)

Crosslinked Gelatin‐Polycaprolactone Scaffolds: Balancing Biocompatibility and Inflammatory Response for Tissue Engineering Applications

Polymer Engineering &Science, EarlyView.
Crosslinked gelatin‐functionalized PCL scaffolds exhibited enhanced hydrophilicity, structural stability, and porous interactions. In vitro assays demonstrated improved osteoblast adhesion, viability, and proliferation without cytotoxicity, while in vivo evaluation showed no adverse inflammatory response, supporting their potential application in ...
Fernanda Ramírez‐Ruiz, Israel Núñez‐Tapia, Lucía Pérez‐Sánchez, María Cristina Piña‐Barba, Irving Sanchez‐Leal, Marco Antonio Alvarez‐Perez, Iriczalli Cruz‐Maya, Janeth Serrano‐Bello   +7 more
wiley   +1 more source

Resolvin D1 alleviates lipopolysaccharide-induced <i>in vitro</i> corneal inflammation by modulating macrophage polarization through upregulation of c-Fos expression. [PDF]

Bioimpacts
Qin Q, Wang Y, Liu Y, An W, He Z, Chen F, Cheng X, Chen D, Xie Z.   +8 more
europepmc   +1 more source

Snapshots of Motion: A Novel Structural Intermediate Reveals Conserved Dynamics in Archaeal DNA Ligases

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT We present the first x‐ray crystallographic structural evidence of an archaeal DNA ligase showing the AMP covalent adduct together with further cofactor hydrolysis, capturing a transient intermediary in the first step of the ligation reaction, triggered by the pyrophosphate hydrolysis.
A. X. Quintana‐Armas, E. Flores‐Hernández, C. Cardona‐Félix, E. Rudiño‐Piñera   +3 more
wiley   +1 more source

Single-Cell Transcriptomic Profiling Reveals That Macrophage-Induced Angiogenesis Contributes to Immunotherapy Resistance in Hepatocellular Carcinoma. [PDF]

Biology (Basel)
Pan X, Liao B, Hu Z, Xiong Y.
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

8-Methoxypeucedanin: Evaluation of Anxiolytic Effects and Modulation of Neuronal Activity Related Genes in a Zebrafish Anxiety Mode. [PDF]

Int J Mol Sci
Widelski J, Maciąg M, Kasica N, Budzyńska B, Podlasz P, Luca SV, Fondai D, Skalicka-Woźniak K.   +7 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

The double-edged sword effect of adverse childhood experiences forging adult stress into depression and anxiety. [PDF]

Sci Rep
Gong Z, Yang J, Wang Y, Liang W, Luo S, Li X, Yue G.   +6 more
europepmc   +1 more source

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina, Stefan Franzén, Maria C. Kjellsson   +2 more
wiley   +1 more source

Subgroup of meningiomas involving FOS and FOSB gene fusions. [PDF]

Nat Commun
Yalcin K, Alanya H, Gultekin B, Samper Figuera D, Barak T, Miyagishima DF, Youngblood MW, Hjerthen MG, Brooks A, Samuel Lopez N, O'Brien J, Chavez MM, Dincer A, Wu H, Omay SB, Yasuno K, Bilguvar K, Ercan-Sencicek AG, Mishra-Gorur K, McGuone D, Moliterno J, Gunel M, Erson-Omay EZ.   +22 more
europepmc   +1 more source