Results 71 to 80 of about 26,336 (149)

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina, Stefan Franzén, Maria C. Kjellsson   +2 more
wiley   +1 more source

Resonant Raman Scattering Study of Strain and Defects in Chemical Vapor Deposition Grown MoS2 Monolayers

Small, EarlyView.
This work unifies the study of effects of local strain and disorder on the Raman and photoluminescence spectra of chemical vapor deposition (CVD) grown semiconducting 2D‐TMDs, shedding light on their influence on the frequency and intensity of second‐order acoustic Raman bands under resonant conditions.
Rafael N. Gontijo, Nathaniel Bunker, Samarra L. Graiser, Xintong Ding, Manuel Smeu, Ana Laura Elías   +5 more
wiley   +1 more source

European Consensus on Malabsorption—UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN

United European Gastroenterology Journal, EarlyView.
ABSTRACT Malabsorption is a complex and multifaceted condition characterised by the defective passage of nutrients into the blood and lymphatic streams. Several congenital or acquired disorders may cause either selective or global malabsorption in both children and adults, such as cystic fibrosis, exocrine pancreatic insufficiency (EPI), coeliac ...
Marco Vincenzo Lenti, Heinz Florian Hammer, Ilja Tacheci, Rosa Burgos, Stephane Schneider, Anastasiou Foteini, Aleksejs Derovs, Jutta Keller, Ilse Broekaert, Marianna Arvanitakis, Dan Lucian Dumitrascu, Oscar Segarra‐Cantón, Željko Krznarić, Juris Pokrotnieks, Gonçalo Nunes, Johann Hammer, Loris Pironi, Marc Sonyi, Cristina Maria Sabo, Juan Mendive, Adrien Nicolau, Jernej Dolinsek, Denisa Kyselova, Lucrezia Laterza, Antonio Gasbarrini, Teodora Surdea‐Blaga, Jorge Fonseca, Christos Lionis, Gino Roberto Corazza, Antonio Di Sabatino   +29 more
wiley   +1 more source

More than fish: diet composition of fishing cats Prionailurus viverrinus in human‐dominated landscape

Wildlife Biology, EarlyView.
The fishing cat Prionailurus viverrinus is a medium‐sized wetland specialist felid threatened primarily by habitat loss, human–wildlife conflict, and road mortality. Limited information is available on their life history in human‐modified environments.
Rama Mishra, Laura Bertola, Herwig Leirs, Sabin Adhikari, Babu Ram Lamichhane, Naresh Subedi, Utsav Neupane, Shekhar S. Kolipaka, Prajwol Manandhar, Saman Man Pradhan, Asmita Pageni, Hans H. de Iongh   +11 more
wiley   +1 more source

Network expression analysis identifies and experimentally validates the involvement of Fosb in acute kidney injury

FASEB BioAdvances, Volume 7, Issue 4, April 2025.
In this study, we used bioinformatics and in vitro and in vivo validations to discover the close association of Fosb with AKI, which was significantly upregulated in AKI. Furthermore, Fosb promoted apoptosis through AP‐1 signaling pathway‐mediated inflammatory responses in renal tubular epithelial cells, suggesting that it has the potential to be a ...
Xiaoyan Tang, Changqiong Shen, Chunqiu Liu, Jianya Gao   +3 more
wiley   +1 more source

Transcriptional Study of Radiofrequency Device Using Experimental Mouse Model. [PDF]

Int J Mol Sci
Li X, Wang Z, Li X, Fan X, Lu X, Li Y, Pan Y, Zhu Z, Zhu M, Li W, Chan L, Yu S, Pan Y, Wu Y.   +13 more
europepmc   +1 more source

Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle

FASEB BioAdvances, EarlyView.
Current model on the effects of acute endurance exercise on the AS regulatory mechanism with key trans‐factors/RBPs (e.g., hnRNP‐A1, ‐A3, and TIA1). ABSTRACT Alternative splicing (AS) is a highly conserved posttranscriptional mechanism, generating mRNA variants to diversify the proteome.
Alexander Ahn, Jeongjin J. Kim, Aaron L. Slusher, Jeffrey Y. Ying, Eric Y. Zhang, Andrew T. Ludlow   +5 more
wiley   +1 more source

Effects of two different peptides on pentylenetetrazole-induced seizures in larval zebrafish. [PDF]

PLoS One
Fernández JAA, de Moura TC, Vila SF, Gaytán JAR, López-Díaz I, Learte-Aymamí S, Vázquez ME, Mayán MD, Sánchez L, Maurer-Morelli CV.   +9 more
europepmc   +1 more source

Classification and statistical analysis of structural disorder in crystalline materials

Journal of Applied Crystallography, EarlyView.
We have developed a new classification system for disorder in crystalline materials based on analysis of the information present in crystallographic information files. By recognizing the role of the proximity of crystallographic sites to each other and the interplay of partial occupancies in creating disorder, we consider seven distinct types of ...
Dmytro Antypov, Chris M. Collins, Matthew S. Dyer, John B. Claridge, Matthew J. Rosseinsky   +4 more
wiley   +1 more source