Results 71 to 80 of about 119 (117)
Arthritis &Rheumatology, Accepted Article.Objectives To elucidate role of beta‐transducin repeat‐containing protein 2 (β‐TrCP2) in bone homeostasis for its potential as a therapeutic target for osteoporosis. Methods The role of β‐TrCP2 in bone phenotypes was investigated using systemic β‐TrCP1KO and β‐TrCP2KO mice, along with myeloid‐specific conditional β‐TrCP2KO (β‐TrCP2ΔM) mice.
Woo Jung Kim +14 more
wiley +1 more source
BMEMat, EarlyView.LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng +4 more
wiley +1 more source
BMEMat, EarlyView.Downregulated CAV1 in HO is restored via apoptotic bodies from PMSCs, which reprogram bone remodeling by delivering CAV1 to target cells, highlighting the therapeutic role of EV subtypes in heterotopic ossification. Abstract Heterotopic ossification (HO) is a pathological process characterized by ectopic bone formation in non‐osseous tissues, with an ...
Yuchen Wang +13 more
wiley +1 more source
A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells
Chemistry – A European Journal, EarlyView.A microbial metabolite covalently binds immunological protein MR1 to potently activate specific lymphocytes called MAIT cells, but it is too unstable for biological applications. Here, using synthesis, assays, protein crystallography, and computer modelling, we report a water‐stable analogue that activates reporter cells expressing the MAIT T cell ...
Jeffrey Y. W. Mak +9 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Novel liquid crystalline fluorenones bearing various head groups were synthesized and characterized. By alteration of the head group, N, SmC, or SmA phases were obtained, and emission properties could be tuned depending on solvent or temperature. ABSTRACT In this work, a series of novel unsymmetrical fluorenone derivatives bearing various head groups ...
Falk Feucht +5 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.The complete series of hexahalogenated triptycene‐tribenzoquinones, comprising newly synthesized fluoro‐, bromo‐, and iodo‐substituted derivatives together with the previously reported chloro analogue, enables systematic comparison of their molecular properties and intermolecular interactions in relation to their crystal packing modes.
Shuta Tsuruga +4 more
wiley +1 more source
The Canadian Journal of Chemical Engineering, EarlyView.Abstract On the centennial of higher education in Chemical Engineering in Mexico, it is pertinent to revisit the key stages that have contributed to its consolidation as a vital discipline for the nation's scientific and technological advancement. Although the initial mission of chemical engineering education was primarily oriented toward the training ...
Agustín López Munguía +3 more
wiley +1 more source
Cytoskeleton, EarlyView.ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith +9 more
wiley +1 more source
Annals of the Child Neurology Society, EarlyView.ABSTRACT Introduction GRIA2 encodes the GluA2 ionotropic α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit. Pathogenic GRIA2 variants cause epilepsy, developmental delay, and neurobehavioral disorders. Characterizations of clinical features, including seizure types and their treatments, in patients with GRIA2‐related ...
Sai Srihitha Dommata +9 more
wiley +1 more source
Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT Sustainability assessment advances corporate social responsibility toward inclusive development. Widely recognized approaches prove inadequate for micro, small, and medium enterprises (MSMEs), resulting in fragmented proliferation that hinders cumulative knowledge.
Luísa Couto Gonçalves de Souza +2 more
wiley +1 more source