Results 71 to 80 of about 118 (117)
Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva +10 more
wiley +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The emergence of antibiotic resistance in bacteria is a major threat to global public health. To combat increasingly drug‐resistant bacteria like Pseudomonas aeruginosa, new targets for pharmaceuticals need to be explored. One such potential target for P.
Philipp Schneider +4 more
wiley +1 more source
The continuing significance of chiral agrochemicals
Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada +13 more
wiley +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina +2 more
wiley +1 more source
Acid Resistant and Highly Silver Selective Membranes Based on Charged Nanoporous 2D‐Materials
Small, EarlyView.In this work, new membranes based on charged & nanoporous nanosheets with unprecedented selectivity to silver versus a wide range of other metallic ions are reported. Furthermore, a demonstrated and lead specific intralamellar lead pathway is demonstrated. A potential applicability for ubiquitous silver in WEEE is validated.
Sarah M. Chevrier +6 more
wiley +1 more source
Porous Organic Polymers: From Molecular Design to Scalable Technologies
Small, EarlyView.This review introduces porous organic polymers (POPs) for a wide range of applications, including energy storage, gas adsorption, catalysts, adsorbents, biomedical applications, sensors, and other exciting fields, and critically analyzes the synthesis and modification, and how structural topology influences the composites' architecture of POPs, along ...
Hossein Mashhadimoslem +12 more
wiley +1 more source
In Situ Heating STEM of the Thickness‐Dependent Evolution of Ferroelastic Domains
Small, EarlyView.In‐situ heating scanning transmission electron microscopy combined with machine‐learning segmentation is used to study the thickness and temperature dependent behavior of ferroelastic domain walls in free‐standing LaAlO3 samples. The results quantify domain wall curvature and density throughout cooling, revealing a pronounced thickness‐dependent ...
Luka Geddis Zellmann +6 more
wiley +1 more source
The Chemical Record, EarlyView.Biomass‐derived carbon provides a sustainable, porous, and conductive scaffold that stabilizes nanomaterials for bifunctional hydrogen evolution reaction/oxygen evolution reaction catalysis. This review summarizes design strategies (defects, heteroatom doping, heterostructures, single atoms), mechanistic/density functional theory insights, degradation ...
Paricha Jebin +8 more
wiley +1 more source
Environmental Toxicology, EarlyView.ABSTRACT The current study aimed to quantify the antimicrobials amoxicillin (AMX), cefazolin (CFZ), chloramphenicol (CHL), metronidazole (MTZ), and sulfamethoxazole (SX) in effluents and surface water of an important Cerrado river, calculate their half‐lives, and analyze their ecotoxicity following single and combined exposures.
Náthala Maria Simão +12 more
wiley +1 more source