Results 81 to 90 of about 118 (117)

A simple and practical approach for protein serial crystallography using grease matrix and large‐area support film

Journal of Synchrotron Radiation, EarlyView.
A simple fixed‐target protein serial crystallography method combining a grease matrix with a large‐area support film enables stable sample handling, low sample consumption, and high‐resolution room‐temperature structure determination.Serial femtosecond crystallography (SFX) enables structural determination of biological macromolecules at room ...
Michihiro Sugahara, Saori Maki-Yonekura, Ichiro Inoue, Kiyofumi Takaba, Shun Narai, Hisashi Naitow, Jungmin Kang, Kensuke Tono, Keiji Numata, Tetsuya Ishikawa, Makina Yabashi, Koji Yonekura   +11 more
wiley   +1 more source

Prevalence and Genomic Characterization of mcr‐Positive Enterobacteriaceae in Retail Meat in Thailand Following the Colistin Ban

Microbiology and Immunology, EarlyView.
ABSTRACT This study aimed to investigate the prevalence and characteristics of mcr‐positive Enterobacteriaceae in retail meat in Thailand following the national ban on prophylactic colistin use in food producing animals. A total of 152 meat samples (103 chicken and 49 pork) were collected from supermarkets and open markets between July and September ...
Ahmed Abououf, Sharda Prasad Awasthi, Asmaa M. Elbastawesy, Noritoshi Hatanaka, Atsushi Hinenoya, Srinuan Somroop, Yukihiro Kaneko, Shinji Yamasaki   +7 more
wiley   +1 more source

Sino‐Mexican Encounters Before the ‘Diplomatic Opening’: Exhibition Diplomacy and Grassroots Friendship in the 1960s

History, EarlyView.
Abstract During the 1960s, Mexico's Institutional Revolutionary Party (PRI) embraced Chinese overtures for a commercial opening as consistent with its anti‐imperialist posture, thereby foreshadowing the diplomatic opening to China in 1972. Yet this professed ideological pluralism was eclipsed by an underlying allegiance to the United States' anti ...
YIXIN TIAN
wiley   +1 more source

THE VIOLENCE OF FULL COST RECOVERY: Financing Water Infrastructure, and the History and Future of Perpetual Crisis in Mombasa

International Journal of Urban and Regional Research, EarlyView.
Abstract Foregrounding the role of finance, this article examines the historical production and future trajectory of the urban water crisis in Mombasa. Drawing on archival research and contemporary fieldwork, it traces how principles of full cost recovery—institutionalized during the colonial period and later reworked through postcolonial ...
Joe Williams
wiley   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm

British Journal of Pharmacology, EarlyView.
Abstract Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms—major contributors to poor outcomes—and are frequently associated with significant side ...
Brian J. Morris, Judith A. Pratt
wiley   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Life and Death in Schelling's Philosophy of Nature

European Journal of Philosophy, EarlyView.
Abstract F. W. J. Schelling's philosophy of nature (Naturphilosophie) has received significant renewed interest and reappraisal. This research has – like the majority of work in the philosophy of nature and the history of science more generally – focused on Schelling's understanding of life, but eschews any discussion of death.
Dalia Nassar
wiley   +1 more source

Neuroimmune alterations and nociceptive behavior in oral carcinogenesis in rats

European Journal of Oral Sciences, EarlyView.
Abstract Oral cancer pain is a frequent and debilitating symptom associated with tumor progression. Although neuronal mechanisms have been extensively studied, the role of immune and glial cells in the trigeminal nociceptive pathway remains poorly understood.
Joana Maria dos Santos Alves, Luiza Clertiani Vieira Alves, Vitória Tavares Bessa, Anamaria Falcão Pereira, Roberto César Pereira Lima Júnior, Mariana Lima Vale, Karuza Maria Alves Pereira, Delane Viana Gondim   +7 more
wiley   +1 more source