Results 151 to 160 of about 542,291 (213)

A Meta‐Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Journal of Sleep Research, EarlyView.
How does sleep deprivation affect the brain? We performed a meta‐analysis of publicly available transcriptional profiling datasets characterising the effects of sleep deprivation on cortical gene expression (n = 293 mice, 16,290 genes) and validated our results in an independent sample (n = 222 mice).
Cosette A. Rhoads, Megan H. Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson Jr., Huda Akil   +8 more
wiley   +1 more source

From advanced imaging to molecular insights: the state of the art in omics for axial spondyloarthritis. [PDF]

Ther Adv Musculoskelet Dis
Arias-de la Rosa I, Martín-Salazar JE, Cuesta-López L, López-Medina C C, Escudero-Contreras A, Collantes-Estévez E, Barbarroja N, Puche-Larrubia MÁ.   +7 more
europepmc   +1 more source

Improving Mental Health Knowledge Among Brazilian Community Health Agents in a Training Program for a Self‐Reported Mental Health Assessment

Public Health Nursing, EarlyView.
ABSTRACT Objectives This study aimed to evaluate a mental health training process that included the implementation of the interRAI Self‐Reported Assessment for Mental Health (SAMH) tool among Community Health Agents (CHAs), to improve knowledge of mental health issues, as well as to assess the tool's feasibility and acceptability.
Matheus R. Dornelles, Sheila G. Câmara, John P. Hirdes, Jamila Geri Tomaschewski Barlem, Thomas Heimann, Alice Hirdes   +5 more
wiley   +1 more source

The P2Y13 receptor-mediated microglial morphological transformation through the p38MAPK signaling pathway contributes to central sensitization in a murine model of chronic migraine. [PDF]

J Headache Pain
Yang Y, Sun S, Qin P, Sun Y, Li H, Wang D, He X, Ge Z, Fan Z, Zhang J, Sun S.   +10 more
europepmc   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Could Different Doses of Dexmedetomidine Be as Effective as Amifostine Against Radiotherapy-Induced Liver Injury in Rats? Evidence from Mitotic, Apoptotic, Oxidative, and Neurogenic Insights. [PDF]

J Clin Med
Beyazal Polat H, Yilmaz H, Demir K, Kilinc K, Gülhan B, Rakici SY, Tumkaya L.   +6 more
europepmc   +1 more source

HHV‐8/KSHV in Solid Organ Transplantation: Current Gaps of Knowledge and Future Directions

Transplant Infectious Disease, EarlyView.
Risk mitigation strategies, including donors/recipients screening, DNAemia monitoring in recipients at risk, CNI‐to‐mTOR inhibitors switch, antivirals, and rituximab for KICS, may mitigate the impact of HHV‐8/KSHV infection in SOT. This review provides an update on KICS, identifies research gaps, and summarizes advances in screening and management ...
Alessandra Mularoni, Andrea Cona, Malgorzata Mikulska, Francesca Pecoraro, Carlotta Piazza, Elda De Vita, Giada Pietrosi, Matteo Bulati, Tiziana Lazzarotto, Mario Luppi   +9 more
wiley   +1 more source

Associations Between Plasma Omega-3 and Fish Oil Use With Risk of Atrial Fibrillation in the UK Biobank. [PDF]

J Am Heart Assoc
O'Keefe E, O'Keefe JH, Tintle NL, Franco WG, Westra J, Harris WS.   +5 more
europepmc   +1 more source

Tocilizumab provides a potential therapeutic option for the management of hyperhaemolysis syndrome in sickle cell disease: A case series and brief narrative overview of the literature

Transfusion Medicine, EarlyView.
Abstract Background and Objectives Hyperhaemolysis syndrome is a life‐threatening complication of transfusion, potentially triggered by macrophage activation, with limited treatment options. Tocilizumab, an anti‐IL6 monoclonal antibody, has mechanistic rationale for use and has been shown to be effective in a small number of cases.
S. Wolf, B. Singh, A. Zaidi, P. Greaves, F. Oyesanya, S. Bennett, B. Kaya, F. Barroso, P. Telfer   +8 more
wiley   +1 more source

FOS and JUN regulate oxidative stress and steroidogenesis in human aldosterone-producing adenomas. [PDF]

Redox Biol
Wei J, Duregon E, Papotti MG, Knösel T, Bidlingmaier M, Sbiera S, Reincke M, Williams TA.   +7 more
europepmc   +1 more source