Results 121 to 130 of about 4,273 (169)

Descending projections from the insular cortex to the lateral parabrachial nucleus facilitate nocifensive behaviors in rats. [PDF]

Pain
Nakaya Y, Hirose K, Kitano K, Zhao G, Kobayashi A, Osaki H, Kobayashi M.   +6 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Shared and divergent alteration of whole-brain connectivity and sensory deficits in multiple autism mouse models. [PDF]

Mol Psychiatry
Hsu TT, Chen CP, Lin MH, Hung TE, Haung TN, Wang CY, Hsueh YP.   +6 more
europepmc   +1 more source

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina, Stefan Franzén, Maria C. Kjellsson   +2 more
wiley   +1 more source

Machine learning-enhanced discovery of a basement membrane-related gene signature in glioblastoma via single-cell and Spatial transcriptomics. [PDF]

J Transl Med
Liu Z, Yang Y, Fang H, Han M, Qi P, Fan Y, Li J, He S, Wang L.   +8 more
europepmc   +1 more source

A Combined Colon Organoid‐Sensory Neuron Model Reveals Epithelial Contribution to Moringin Efficacy Against Painful Inflammatory Bowel Disease

Phytotherapy Research, EarlyView.
Experimental workflow and main findings of the study. ABSTRACT Visceral pain is a major symptom of inflammatory bowel diseases (IBDs), requiring effective treatment strategies. Gut epithelium, beyond maintaining barrier integrity and microbiota homeostasis, modulates neurosensorial circuitries, influencing visceral sensitivity.
Francesco Margiotta, Elena Lucarini, Alessandra Toti, Maria Giovanna Cataldi, Clara Ciampi, Gina Rosalinda De Nicola, Lorenzo Di Cesare Mannelli, Carla Ghelardini   +7 more
wiley   +1 more source

Protein phosphatase 2A methylation state impacts α-synucleinopathy in mouse models. [PDF]

Cell Death Discov
Maddila S, Hassanzadeh K, Liu J, Zhang J, Ullah F, Nichols RE, Mouradian MM.   +6 more
europepmc   +1 more source

Improving forest age estimation to understand subtropical forest regrowth dynamics using deep learning image segmentation of time‐series historical aerial photographs

Remote Sensing in Ecology and Conservation, EarlyView.
Accurately estimating forest age is key to understanding how forests recover and evaluating restoration success. We developed a two‐step deep learning approach using historical greyscale aerial photographs to map forest age at fine spatial scales. By combining a pre‐trained model with localized fine‐tuning, our U‐Net + ResNet50 architecture achieved ...
Ying Ki Law, Yi‐Fei Gu, Shuwen Liu, Guangqin Song, Aland H. Y. Chan, Cham Man Tse, Zhonghua Liu, Martha J. Ledger, Billy C. H. Hau, Sawaid Abbas, Jin Wu   +10 more
wiley   +1 more source

Effects of two different peptides on pentylenetetrazole-induced seizures in larval zebrafish. [PDF]

PLoS One
Fernández JAA, de Moura TC, Vila SF, Gaytán JAR, López-Díaz I, Learte-Aymamí S, Vázquez ME, Mayán MD, Sánchez L, Maurer-Morelli CV.   +9 more
europepmc   +1 more source

Moment‐curvature behavior of continuous reinforced concrete slab strips—Experimental determination and modeling

Structural Concrete, EarlyView.
Abstract With the market introduction of new reinforcing materials, such as corrosion‐resistant steel, the effect of their stress–strain relationship on the ductility of reinforced concrete structures needs to be evaluated. Their moment‐curvature behavior significantly influences bending moment redistributions, rotation capacity, and deformation at ...
Nathalie Reckinger, Karel Thoma, Walter Kaufmann   +2 more
wiley   +1 more source