Results 111 to 120 of about 4,378 (168)

A Review of Advances in Composite Materials, Structural Optimization, and Machine Learning for Wind Turbine Blades: Challenges and Future Perspectives

Polymer Composites, EarlyView.
Overview of the holistic engineering lifecycle and core research pillars for wind turbine blades. ABSTRACT This paper reviews recent advancements across the lifecycle of wind turbine blades, focusing on three interconnected areas: advanced composites, structural optimization, and machine learning (ML) diagnostics. In materials, we highlight progress in
Kemal Hasirci, Denizhan Yavas, Alaeddin Burak Irez   +2 more
wiley   +1 more source

Solids Conveying in Injection Molding Machines—Analytical Model for Smooth and Grooved Feed Sections Derived From DEM Simulations

Polymer Engineering &Science, EarlyView.
Understanding Solids Conveying in Injection Molding Machines – Dimensions. ABSTRACT Solids conveying is a key aspect for the design of polymer processing machines, especially for processes with high screw speeds, grooved feed sections, and material with low bulk density.
Jan Landgraeber, Volker Schoeppner, Dennis Kleinschmidt, Dominik Jonek, Nils Grieger   +4 more
wiley   +1 more source

Disrupted theta synchronization and synaptic connectivity in the visual cortex of Fmr1 KO mice. [PDF]

Nat Commun
Cheng X, Nareddula S, Gao HC, Chen Y, Xiao T, Nadew YY, Xu F, Edens PA, Saldarriaga V, Hu X, Quinn CJ, Kimbrough A, Huang F, Chubykin AA.   +13 more
europepmc   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Electroacupuncture facilitates remote fear memory erasure via promoting perineuronal net degradation. [PDF]

Transl Psychiatry
Teng SW, Guo WB, Song BF, He YZ, Wang KY, Gao SB, Li W, Chen ZY.   +7 more
europepmc   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

A framework to determine active neurons and networks within the mouse brain reveals how brain activity changes over the course of the day. [PDF]

PLoS Biol
Sun G, Mano T, Shi S, Li A, Ode KL, Rosi-Andersen A, Pedron E, Brown SA, Ueda HR, Kompotis K, Forger DB.   +10 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Gene expression alterations in testicular biopsies from males with spermatogenesis arrest identified by transcriptome analysis. [PDF]

PLoS One
Batiha O, Al-Zoubi E, Almomani R, Al Smadi MA, Alrawabdeh S, Alshokaibi O, Abu-Farsakh H, Alkhateeb A, Abu-Halima M.   +8 more
europepmc   +1 more source

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina, Stefan Franzén, Maria C. Kjellsson   +2 more
wiley   +1 more source