Results 101 to 110 of about 33,550 (169)

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

open access: yesInterdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li   +24 more
wiley   +1 more source

Indirubin and Retinoic Acid Show Binding Affinity to Monocyte Biomarker CSF3R in Parkinson's Disease

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
Through single‐cell RNA‐sequencing and high‐dimensional weighted gene co‐expression network analysis, two monocyte‐related biomarkers (CSF3R, IFITM3) were identified in the peripheral blood of Parkinson's disease. Molecular docking revealed two targeted drugs (Indirubin and Retinoic acid).
Zhiwei Bao, Shao Zhi, Mao Jie
wiley   +1 more source

Prolonged Turnaround Time of the Hematology Laboratory and Related Factors in the South Gondar Zone, North West Ethiopia, Multi‐Centered Study

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
Long turnaround times were prevalent in the hematology laboratories of South Gonder zone hospitals, predominantly as a result of staff incompetence. Clotted blood samples, low blood fill levels, and the day of the week were significant factors linked to delays, with samples collected on Friday having a higher likelihood of prolonged turnaround time ...
Birhanemaskal Malkamu   +19 more
wiley   +1 more source

GLP-1R biased cAMP agonism maintains glycemic control with reduced malaise and emesis in preclinical mammalian models. [PDF]

open access: yesDiabetes Obes Metab
Baumer-Harrison C   +18 more
europepmc   +1 more source

Egg yolk hydrolysate shows moderate impact on osteoporosis in ovariectomized rats

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND This study investigated the protective effect of egg yolk hydrolysate (FC) on osteoporosis in ovariectomized (OVX) rats, a well‐established model of postmenopausal bone loss. OVX rats were fed diets supplemented with 0.2% or 1% FC for 13 weeks.
Ilekuttige Priyan Shanura Fernando   +4 more
wiley   +1 more source

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