Results 1 to 10 of about 477 (199)

miR-146a targets c-Fos expression in human cardiac cells [PDF]

Disease Models & Mechanisms, 2015
miR-146a is a microRNA whose transcript levels are induced in the heart upon activation of NF-κB, a transcription factor induced by pro-inflammatory molecules strongly related to the pathogenesis of cardiac disorders. The main goal of this study consisted in studying new roles of miR-146a in cardiac pathological processes caused by the pro-inflammatory
Palomer, Xavier, Capdevila-Busquets, Eva, Botteri, Gaia, Davidson, Mercy M, Rodríguez, Cristina, Martínez-González, José, Vidal, Francisco, Barroso, Emma, Chan, Tung O, Feldman, Arthur M, Vázquez-Carrera, Manuel   +10 more
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The protooncogene c-fos is transcriptionally active in normal human granulocytes [PDF]

Blood, 1987
Abstract Total cellular RNA of highly purified normal human blood cell populations was analyzed for the expression of the protooncogene c-fos, the cellular counterpart of the transforming FBJ virus. In marked contrast to previous findings based on in vitro studies with permanent leukemic cell lines, c-fos transcription was restricted to ...
K, Heidorn, H, Kreipe, H J, Radzun, R, Müller, M R, Parwaresch   +4 more
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Expression of the c-fos protooncogene by human and murine erythroblasts [PDF]

Blood, 1989
Abstract The expression of the c-fos protooncogene was investigated by in situ hybridization in normal murine bone marrow cells. A strong signal was found in murine marrow cells having the morphologic features of erythroblasts. This result was confirmed in human marrow cells using a double labeling technique (in situ hybridization and ...
J F, Caubet, M T, Mitjavila, A, Dubart, D, Roten, S C, Weil, W, Vainchenker   +5 more
openaire   +3 more sources

Glucocorticoids decrease c-fos expression in human nasal polyps in vivo [PDF]

Thorax, 1998
Activated c-fos binds to jun proteins to form the activation protein 1 (AP-1) transcription factor that regulates cytokine and other proinflammatory genes. c-Fos may play a key role in nasal polyp formation. Glucocorticoids may exert their anti-inflammatory effects through an interaction of glucocorticoid receptors with AP-1 that leads to mutual ...
J N, Baraniuk, G, Wong, M, Ali, M, Sabol, T, Troost   +4 more
openaire   +2 more sources

Fos immunoreactivity assessment on human normal and pathological bronchial biopsies

Respiratory Medicine, 1995
The transcription factor Fos is involved in cell proliferation and differentiation. Its expression in normal and pathological adult human tissues and cells has rarely been studied. We therefore studied bronchial biopsies obtained from 14 normal subjects (NS), 18 non-steroid-treated asthmatics, 10 corticosteroid-treated asthmatics and 10 patients with ...
Demoly, P., Chanez, P., Pujol, J-L., Gauthier-Rouvière, C., Michel, F-B., Godard, P., Bousquet, J.   +6 more
openaire   +2 more sources

Expression of the proto-oncogene c-fos and the immunolocalization of c-fos, phosphorylated c-fos and estrogen receptor beta in the human testis.

Histology and histopathology, 2009
Spermatogenesis is under the control of a complex endocrine and paracrine system, including estrogen receptor (ER) signaling. In many target cells, ER promotes the transcription of c-fos and other proto-oncogenes to regulate cell growth and differentiation.
Araújo, Fabiano C., Oliveira, Cleida A., Reis, Augusto E., Del Puerto, Helen L., Martins, Almir S., Reis, Fernando M.   +5 more
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Human c-fos oncogene mapped within chromosomal region 14q21----q31. [PDF]

Proceedings of the National Academy of Sciences, 1984
The human cellular homolog (c-fos) of the transforming gene of Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus was mapped to a single human chromosome. DNA from a series of 31 mouse-human somatic cell hybrid lines was probed with v- and c-fos molecular clones by Southern blotting.
P E, Barker, M, Rabin, M, Watson, W R, Breg, F H, Ruddle, I M, Verma   +5 more
openaire   +2 more sources

Fos and Jun Proteins Are Specifically Expressed During Differentiation of Human Keratinocytes [PDF]

Journal of Investigative Dermatology, 2005
Activator protein 1 (AP-1) proteins play key roles in the regulation of cell proliferation and differentiation. In this study we investigated the expression of Fos and Jun proteins in different models of terminal differentiation of human keratinocytes and in skin from psoriasis patients.
Mehic, Denis, Bakiri, Latifa, Ghannadan, Minoo, Wagner, Erwin F., Tschachler, Erwin   +4 more
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c-Fos induces chondrogenic tumor formation in immortalized human mesenchymal progenitor cells [PDF]

Scientific Reports, 2018
AbstractMesenchymal progenitor cells (MPCs) have been hypothesized as cells of origin for sarcomas, and c-Fos transcription factor has been showed to act as an oncogene in bone tumors. In this study, we show c-Fos is present in most sarcomas with chondral phenotype, while multiple other genes are related to c-Fos expression pattern.
Ander Abarrategi, Stefano Gambera, Arantzazu Alfranca, Miguel A. Rodriguez-Milla, Raquel Perez-Tavarez, Kevin Rouault-Pierre, Alexander Waclawiczek, Probir Chakravarty, Francisca Mulero, César Trigueros, Samuel Navarro, Dominique Bonnet, Javier García-Castro   +12 more
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The human cytomegalovirus G-protein coupled receptor US28 promotes latency by attenuating c-fos [PDF]

Proceedings of the National Academy of Sciences, 2018
AbstractHuman cytomegalovirus (HCMV) is a ubiquitous pathogen that undergoes latency in cells of the hematopoietic compartment, though the mechanisms underlying establishment and maintenance of latency remain elusive. We previously reported that the HCMV-encoded G-protein coupled receptor (GPCR) homolog,US28is required for successful latent infection ...
Krishna, Benjamin A., Humby, Monica S., Miller, William E., O’Connor, Christine M.   +3 more
openaire   +2 more sources