Results 1 to 10 of about 5,543,352 (313)

Current Opinion on the Use of c-Fos in Neuroscience

NeuroSci, 2022
For years, the biochemical processes that are triggered by harmful and non-harmful stimuli at the central nervous system level have been extensively studied by the scientific community through numerous techniques and animal models.
Sandra Yasbeth Lara Aparicio, Ángel de Jesús Laureani Fierro, Gonzalo Emiliano Aranda Abreu, Rebeca Toledo Cárdenas, Luis Isauro García Hernández, Genaro Alfonso Coria Ávila, Fausto Rojas Durán, María Elena Hernández Aguilar, Jorge Manzo Denes, Lizbeth Donají Chi-Castañeda, César Antonio Pérez Estudillo   +10 more
doaj   +2 more sources

Identification of Fos target genes by the use of selective induction systems

Journal of Cell Science, 1992
ABSTRACT c-Fos is a major component of the transcription factor AP-1 which has been implicated in the control of cell proliferation and differentiation as well as in transformation. In order to identify Fos target genes involved in these processes, we have taken advantage of the regulatory properties of the hormone-binding domain of the ...
S. Braselmann, G. Bergers, C. Wrighton, P. Graninger, G. Superti‐Furga, M. Busslinger   +5 more
semanticscholar   +3 more sources

Targeting the senescence-related genes MAPK12 and FOS to alleviate osteoarthritis

Journal of Orthopaedic Translation
Background: The mechanism by which chondrocyte senescence aggravate OA progression has not yet been well elucidated. The aim of this study was to investigate the chondrocyte senescence related gene biosignatures in OA, and to analyze on the underlying ...
Nana Geng, Menglin Xian, Lin Deng, Biao Kuang, Yiming Pan, Kaiwen Liu, Yuanlan Ye, Mengtian Fan, Zhixun Bai, Fengjin Guo   +9 more
doaj   +3 more sources

FOS-ANKH and FOS-RUNX2 Fusion Genes in Osteoblastoma [PDF]

Cancer Genomics - Proteomics, 2020
Osteoblastoma is a rare benign tumor of the bones in which recurrent rearrangements of FOS have been found. Our aim was to investigate two osteoblastomas for possible genetic aberrations.Cytogenetic, RNA sequencing, and molecular analyses were performed.A FOS-ANKH transcript was found in the first tumor, whereas a FOS-RUNX2 was detected in the second ...
Panagopoulos, Ioannis, Gorunova, Ludmila, Lobmaier, Ingvild Victoria Koren, Andersen, Kristin, Kostolomov, Ilya, Lund-Iversen, Marius, Bjerkehagen, Bodil, Heim, Sverre   +7 more
openaire   +3 more sources

FOS Rescues Neuronal Differentiation of Sox2-Deleted Neural Stem Cells by Genome-Wide Regulation of Common SOX2 and AP1(FOS-JUN) Target Genes

Cells, 2021
The transcription factor SOX2 is important for brain development and for neural stem cells (NSC) maintenance. Sox2-deleted (Sox2-del) NSC from neonatal mouse brain are lost after few passages in culture.
Miriam Pagin, Mattias Pernebrink, Mattia Pitasi, Federica Malighetti, Chew-Yee Ngan, Sergio Ottolenghi, Giulio Pavesi, Claudio Cantù, Silvia K. Nicolis   +8 more
doaj   +1 more source

Identification of signature genes for renal ischemia‒reperfusion injury based on machine learning and WGCNA

Heliyon, 2023
Background: As an inevitable event after kidney transplantation, ischemia‒reperfusion injury (IRI) can lead to a decrease in kidney transplant success. The search for signature genes of renal ischemia‒reperfusion injury (RIRI) is helpful in improving the
Zechao Lu, Senkai Xu, Haiqin Liao, Yixin Zhang, Zeguang Lu, Zhibiao Li, Yushu Chen, Feng Guo, Fucai Tang, Zhaohui He   +9 more
doaj   +1 more source

Fos Facilitates Gallid Alpha-Herpesvirus 1 Infection by Transcriptional Control of Host Metabolic Genes and Viral Immediate Early Gene

Viruses, 2021
Gallid alpha-herpesvirus 1, also known as avian infectious laryngotracheitis virus (ILTV), continues to cause huge economic losses to the poultry industry worldwide.
Zhitao Wang, Yangyang Qiao, Zhijie Chen, Yumeng Liang, Lu Cui, Yanhui Zhang, Xuefeng Li, Li Xu, Ping Wei, Shengwang Liu, Hai Li   +10 more
doaj   +1 more source

Expression of CCL2, FOS, and JUN May Help to Distinguish Patients With IgA Nephropathy From Healthy Controls

Frontiers in Physiology, 2022
BackgroundIgA nephropathy (IgAN), the most common type of glomerulonephritis worldwide, can only be diagnosed mainly by renal biopsy owing to lack of effective biomarkers.
Xue Zhou, Xue Zhou, Xue Zhou, Ning Wang, Yuefeng Zhang, Pei Yu, Pei Yu   +6 more
doaj   +1 more source

The FOS/AP-1 regulates metabolic changes and cholesterol synthesis in human periovulatory granulosa cells.

Endocrinology, 2021
FOS, a subunit of the activator protein-1 (AP-1) transcription factor, has been implicated in various cellular changes. In the human ovary, the expression of FOS and its heterodimeric binding partners JUN, JUNB, and JUND increases in periovulatory ...
Yohan Choi, H. Jeon, J. Akin, T. Curry, Misung Jo   +4 more
semanticscholar   +1 more source

New kids on the block: FOS and FOSB gene

Journal of Clinical Pathology, 2023
FOS and FOSB proto-oncogens are involved in a wide variety of tumourigenic processes. FOS and FOSB gene rearrangements are observed in epithelioid haemangioma, pseudomyogenic ...
Fleur Cordier, David Creytens
openaire   +3 more sources