Results 31 to 40 of about 5,543,352 (313)

c-Jun/c-Fos heterodimers regulate cellular genes via a newly identified class of methylated DNA sequence motifs

Nucleic Acids Research, 2013
CpG methylation in mammalian DNA is known to interfere with gene expression by inhibiting the binding of transactivators to their cognate sequence motifs or recruiting proteins involved in gene repression.
Montse Gustems, Anne Woellmer, Ulrich Rothbauer, S. Eck, T. Wieland, D. Lutter, W. Hammerschmidt   +6 more
semanticscholar   +1 more source

Local Morphine Withdrawal Increases c-fosGene, Fos Protein, and Oxytocin Gene Expression in Hypothalamic Magnocellular Neurosecretory Cells [PDF]

The Journal of Neuroscience, 2000
We measured stimulation of c-fosand oxytocin gene expression during excitation of oxytocin cells induced by systemic or local morphine withdrawal. Female rats were made morphine-dependent by intracerebroventricular morphine infusion over 5 d. Morphine withdrawal, induced by systemic injection of the opioid antagonist naloxone (5 mg/kg) in conscious or ...
L E, Johnstone, C H, Brown, H K, Meeren, C L, Vuijst, P J, Brooks, G, Leng, J A, Russell   +6 more
openaire   +2 more sources

Screening and Identification of Key Genes for Activation of Islet Stellate Cell

Frontiers in Endocrinology, 2021
BackgroundIt has been demonstrated that activated islet stellate cells (ISCs) play a critical role in islet fibrogenesis and significantly contribute to the progression of type 2 diabetes mellitus.
Xiaohang Wang, Vladmir Carvalho, Qianqian Wang, Jinbang Wang, Tingting Li, Yang Chen, Chengming Ni, Lili Liu, Yang Yuan, Shanhu Qiu, Zilin Sun   +10 more
doaj   +1 more source

Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace

Frontiers in Molecular Neuroscience, 2016
In the brain, neuronal gene expression is dynamically changed in response to neuronal activity. In particular, the expression of immediate-early genes (IEGs) such as egr-1, c-fos, and Arc is rapidly and selectively upregulated in subsets of neurons in ...
Keiichiro Minatohara, M. Akiyoshi, H. Okuno   +2 more
semanticscholar   +1 more source

A mutation in the c-Fos gene associated with congenital generalized lipodystrophy [PDF]

Orphanet Journal of Rare Diseases, 2013
Abstract Background Congenital generalized lipodystrophy (CGL) or Berardinelli–Seip congenital lipodystrophy (BSCL) is a rare genetic syndrome characterized by the absence of adipose tissue. As CGL is thought to be related to malfunctions in adipocyte development, genes involved in the mechanisms of adipocyte biology ...
Knebel, Birgit, Kotzka, Jorg, Lehr, Stefan, Hartwig, Sonja, Avci, Haluk, Jacob, Sylvia, Nitzgen, Ulrike, Schiller, Martina, März, Winfried, Hoffmann, Michael M., Seemanova, Eva, Haas, Jutta, Müller-Wieland, Dirk   +12 more
openaire   +3 more sources

The EGR1-FOS Transcriptional Axis in Liver Fibrosis: An Integrated Bioinformatic Analysis of Disease Progression and Shared Molecular Signatures in Cirrhosis

BioMedInformatics
Background: Liver fibrosis arises from chronic liver injury and remains a major clinical challenge due to its progression toward cirrhosis and hepatocellular carcinoma, as well as the absence of approved antifibrotic therapies.
Youssef Nadir, Hicham Esselmani, Anass Oukhdouch, Habiba Nechchadi, Rahma Ennadi, Mohammed Amine Lkousse, Issame Farouk, Mustapha Najimi, Mohamed Merzouki   +8 more
doaj   +1 more source

A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry

Journal of Neuroscience, 1993
The promoter regions of the rat corticotropin-releasing factor (CRF), oxytocin (OT), and vasopressin (AVP) genes contain sequences similar to the cis-acting response element identified for NGFI-B, an immediate- early gene structurally related to the ...
R. Chan, E. Brown, A. Ericsson, K. Kovács, P. Sawchenko   +4 more
semanticscholar   +1 more source

Identification of a Novel Gene Correlated With Vascular Smooth Muscle Cells Proliferation and Migration in Chronic Thromboembolic Pulmonary Hypertension

Frontiers in Physiology, 2021
Objective: Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by thrombofibrotic obstruction of the proximal pulmonary arteries, which result in vascular remodeling of the distal pulmonary artery.
Feng Wang, Feng Wang, Congrui Sun, Xiaoshuo Lv, Xiaoshuo Lv, Mingsheng Sun, Chaozeng Si, Yanan Zhen, Jing Guo, Weiliang Sun, Zhidong Ye, Jianyan Wen, Jianyan Wen, Peng Liu, Peng Liu   +14 more
doaj   +1 more source

Targeted disruption of the c‐fos gene demonstrates c‐fos‐dependent and ‐independent pathways for gene expression stimulated by growth factors or oncogenes.

The EMBO Journal, 1994
The c-fos proto-oncogene is believed to play a pivotal role in transducing growth factor-mediated signals from the extracellular milieu into the nucleus. c-fos protein dimerizes with c-jun and related proteins and mediates transcription via AP-1 sites. Using c-fos-deficient mice generated through gene knockout techniques, we derived 3T3-type cell lines
Hu E., Mueller E., Oliviero S., Papaioannou V. E., Johnson R., Spiegelman B. M.   +5 more
openaire   +4 more sources

Screening and Identification of Hub Genes in the Development of Early Diabetic Kidney Disease Based on Weighted Gene Co-Expression Network Analysis

Frontiers in Endocrinology, 2022
ObjectiveThe study aimed to screen key genes in early diabetic kidney disease (DKD) and predict their biological functions and signaling pathways using bioinformatics analysis of gene chips interrelated to early DKD in the Gene Expression Omnibus ...
Ran Wei, Jingtao Qiao, Di Cui, Qi Pan, Lixin Guo   +4 more
doaj   +1 more source