Results 171 to 180 of about 20,989 (216)

Hippocampal neuronal hypoexcitability contributes to PTSD-like phenotypes in the experimental autoimmune encephalomyelitis model. [PDF]

Front Psychiatry
Zhong X, Zhang H, Xie J, Gao Y, Wang H, Peng Y, Yi F, Chen J.   +7 more
europepmc   +1 more source

Single‐Cell Virtual Perturbation Screening Identifies STAT3 as a Key Regulator of Dentinogenesis

Cell Proliferation, EarlyView.
STAT3 promotes odontoblast differentiation in dental mesenchymal cells by transcriptionally regulating WNT2B via the canonical Wnt/β‐catenin signalling pathway. These findings elucidate a mechanism underlying dentine development. ABSTRACT Dentine formation constitutes a physiological process precisely regulated by signal transduction modules governing ...
Yanfei Zhu, Hongyuan Xu, Zijian Zhang, Siyuan Sun, Zihan Huang, Xin Gao, Houwen Pan, Xiangru Huang, Yuanqi Liu, Xinyu Wang, Hanbin Jia, Qinggang Dai, Lingyong Jiang   +12 more
wiley   +1 more source

Mediodorsal thalamus of alcohol-dependent mice shows genetic and physiological adaptations and alcohol-biased calcium signaling. [PDF]

Neuropharmacology
Martin JC, Reeves KC, Carter KA, Davis M, Schneider A, Meade E, Lebonville CL, Nimitvilai-Roberts S, Hoffman M, Woodward JJ, Loewinger G, Smith RJ, Lopez MF, Becker HC, Mulholland PJ, Rinker JA.   +15 more
europepmc   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, EarlyView.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Sugarcane Biorefinery from Component Separation to High-Value Outputs: Technical Progress and Future Perspectives. [PDF]

Foods
Dai J, Chen J, Lin B, Lu L, Zheng F, Verma KK, Chen G.   +6 more
europepmc   +1 more source

Between famine and freedom: Food prices during the Indonesian War of Independence, 1945–9

The Economic History Review, EarlyView.
Abstract This paper investigates how the Indonesian War of Independence (1945‒9) influenced staple food prices, and how fluctuations in those prices, in turn, shaped the trajectory and dynamics of the conflict. We compiled a dataset comprising more than 8600 prices for staple foods covering the entire Indonesian archipelago from 1939‒49, allowing us to
Ingrid de Zwarte, Helmi Moret, Pim de Zwart   +2 more
wiley   +1 more source

Identification of Cell Subpopulation-Specific Driver Genes Reveals Ideal Candidates for Renal Cell Carcinoma Immunotherapy. [PDF]

Int J Mol Sci
Yin X, Wang L, Sun Y, Li S, Yu W, Wang S, Geng Z, Zhao H, Wang L.   +8 more
europepmc   +1 more source

A distinct gene expression mechanism for d‐amino acid utilization in hyperthermophilic archaeon Pyrococcus horikoshii

The FEBS Journal, EarlyView.
The genes PH0137, PH0138, and PH0140 form a cluster in the genome of Pyrococcus horikoshii. The PH0140 gene encodes a transcription factor identified as a d‐amino acid‐responsive regulatory protein (DARP). In feast mode, l‐Ile‐bound DARP binds to the promoter and represses transcription of PH0137 and PH0138. In famine mode, DARP binds to d‐allo‐Ile and
Ryushi Kawakami, Tomoki Kawase, Taira Uehara, Haruhiko Sakuraba, Tomohiko Matsuzawa, Junji Hayashi, Toshihisa Ohshima   +6 more
wiley   +1 more source

Integrated geotechnical and geomorphological implication of urbanization on slope stability in the vicinity of GRA hills Nsukka southeast Nigeria. [PDF]

Sci Rep
Nwafor EN, Igwe O, Ukor KP, Eze KN, Ozioko OH, Ezea UJ.   +5 more
europepmc   +1 more source

From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system

The FEBS Journal, EarlyView.
The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger, Alice Wiedmann, Rayan Hassan M. Elshikhidriss, Thomas Brunner   +3 more
wiley   +1 more source