Results 141 to 150 of about 490 (192)

Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms

Allergy, EarlyView.
Short‐term exposure to SDS rapidly disrupts human skin barrier integrity within minutes, as detected by real‐time electrical impedance spectroscopy. SDS‐induced barrier dysfunction is driven by oxidative stress, leading to suppression of immune/barrier mediators and activation of stress, lipid remodeling, and epidermal differentiation pathways ...
Manru Li, Huseyn Babayev, Paolo D'Avino, Can Zeyneloğlu, Ceren Bicer, Duygu Yazici, Yagiz Pat, Per Svedenhag, Nicolas Gaudenzio, Cezmi A. Akdis, Yasutaka Mitamura   +10 more
wiley   +1 more source

A scheduling perspective on modular educational systems in Europe. [PDF]

Heliyon
Ruiz-Torrubiano R, Knopp S, Krystallidis A, Wolf LM.   +3 more
europepmc   +1 more source

Prevention of microglial activation and postoperative cognitive deficits by positive allosteric modulation of α5‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Long‐lasting cognitive deficits after surgery in aged individuals, referred to as perioperative neurocognitive disorder (NCD), are a significant public health concern. Such postoperative cognitive deficits are dependent on the presence of microglia in the brain, which, when activated, trigger neuroinflammation.
Jinrui Lyu, Rajasekar Nagarajan, Dishary Sharmin, Prithu Mondal, Maltesh Kambali, Muxiao Wang, Jinyan Zhou, Makoto Inoue, James M. Cook, Uwe Rudolph   +9 more
wiley   +1 more source

Repeat-element RNAs integrate a neuronal growth circuit.

Cell
Zahavi EE, Koppel I, Kawaguchi R, Oses-Prieto JA, Briner A, Monavarfeshani A, Dalla Costa I, van Niekerk E, Lee J, Matoo S, Hegarty S, Donahue RJ, Sahoo PK, Ben-Dor S, Feldmesser E, Ryvkin J, Leshkowitz D, Perry RB, Cheng Y, Farber E, Abraham O, Samra N, Okladnikov N, Alber S, Albus CA, Rishal I, Ulitsky I, Tuszynski MH, Twiss JL, He Z, Burlingame AL, Fainzilber M.   +31 more
europepmc   +1 more source

The effect of acupuncture on blood glucose control in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Front Endocrinol (Lausanne)
Si Y, Chen J, Chen L, Zheng Y, Qiu Y, Wang B, Liang Y, Zhang Y, Chen Y.   +8 more
europepmc   +1 more source

Toll‐like receptor 4 mediates lipopolysaccharide‐induced emesis

British Journal of Pharmacology, EarlyView.
Background and Purpose Lipopolysaccharide (LPS) induces inflammation and sepsis through Toll‐like receptor 4 (TLR4) activation. Common laboratory animals do not exhibit emesis, but administration of LPS in piglets, cats, and dogs induces emesis via peripheral mechanisms.
Luping Liu, Zengbing Lu, Julia Yuen Hang Liu, Man Piu Ngan, Kai‐Hei Tse, John Anthony Rudd   +5 more
wiley   +1 more source

Biodesign and plant sciences: Evolving STEAM pedagogies in higher education. [PDF]

Quant Plant Biol
Danies G, Obregón C, Ojeda-Ramírez S, Burbano A.   +3 more
europepmc   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Chemical linkers switch triglycerol detergents from bacterial protein purification to mild antibiotic amplification. [PDF]

Commun Chem
Singh AK, Seewald M, Schade B, Zoister C, Haag R, Urner LH.   +5 more
europepmc   +1 more source

A cDC1‐NK/T‐Malignant Cell Circuit Drives Immunogenic Remodeling Under PD‐1 Blockade in Gastric Cancer

Cancer Science, EarlyView.
Chemotherapy combined with nivolumab reshapes the gastric cancer tumor microenvironment (TME) and is accompanied by an enrichment of reduced cytotoxicity NK (RC‐NK) cells. Rather than acting as classical cytotoxic effectors, these RC‐NK cells appear to shape the TME by promoting an immunostimulatory circuit that engages adaptive immunity.
Takuya Nakatsuru, Hiroki Yamashita, Chiaki Mashima, Guoqiang Zhang, Hitoshi Saito, Tatsunori Minamide, Keita H. Nagaoka, Ryo Kamata, Shunsuke A. Sakai, Gaku Yamamoto, Tomoko Y. Morita, Kazuki Nakai, Yumi Hakozaki, Kumi Kinoshita, Yui Takahashi, Izuma Nakayama, Akihito Kawazoe, Yuko Ishii, Sai M. Pulukuri, Hiroshi Haeno, Yukie Kashima, Kohei Shitara, Tomonori Yano, Takeshi Saito, Akihiro Ohashi   +24 more
wiley   +1 more source