Results 121 to 130 of about 487 (170)

Perspectives of stakeholders on post-trial access arrangements in Ethiopia: a qualitative study. [PDF]

Glob Bioeth
Tucho GT, Wangamati CK, Kumsa DM, Bernabe RC.   +3 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Targeting the gut microbiome for type 2 diabetes management: a scoping review of systematic reviews and meta-analyses. [PDF]

Front Endocrinol (Lausanne)
Jiang R, Zheng L, Fang J, Guan Q, Yuan H, Liang J, Zhang J, Han Q, Liu M.   +8 more
europepmc   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

Repeat-element RNAs integrate a neuronal growth circuit.

Cell
Zahavi EE, Koppel I, Kawaguchi R, Oses-Prieto JA, Briner A, Monavarfeshani A, Dalla Costa I, van Niekerk E, Lee J, Matoo S, Hegarty S, Donahue RJ, Sahoo PK, Ben-Dor S, Feldmesser E, Ryvkin J, Leshkowitz D, Perry RB, Cheng Y, Farber E, Abraham O, Samra N, Okladnikov N, Alber S, Albus CA, Rishal I, Ulitsky I, Tuszynski MH, Twiss JL, He Z, Burlingame AL, Fainzilber M.   +31 more
europepmc   +1 more source

Application of the miRNAs as biomarkers and therapeutic strategies in periodontal inflammation. [PDF]

Front Pharmacol
Saha S, Sachivkina N, Pilshchikova O, Muraev A, Ivanov S, Ivashkevich SG, Gurina R.   +6 more
europepmc   +1 more source

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

Identification of a nuclear transcriptional module associated with ERα and E2F/FOXM1 signaling across PAM50 breast cancer subtypes. [PDF]

Front Oncol
Dozal-Luna AJ, Santuario-Facio SK, Cardona-Huerta S, Gómez-Macías GS, Rangel-Escareno C, Lira-Albarrán S, Gómez-Flores-Ramos L, Ortiz-López R.   +7 more
europepmc   +1 more source

Sliding Mode Control and Observation for Upper Limb Robotics Rehabilitation

International Journal of Robust and Nonlinear Control, EarlyView.
ABSTRACT Stroke is a leading cause of upper limb motor impairments, which often require rehabilitation. General purpose robotic manipulators enable effective therapy through exercises such as Center Out Point‐to‐Point (CO‐PTP) and Teach‐and‐Track (TT), which respectively demand accurate estimation and rejection of the interaction force exerted by the ...
Antonella Ferrara, Chiara Alessi, Nikolas Sacchi   +2 more
wiley   +1 more source

A scheduling perspective on modular educational systems in Europe. [PDF]

Heliyon
Ruiz-Torrubiano R, Knopp S, Krystallidis A, Wolf LM.   +3 more
europepmc   +1 more source