Results 121 to 130 of about 499,874 (389)

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

open access: yesAdvanced Science, EarlyView.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao   +15 more
wiley   +1 more source

Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity

open access: yesAdvanced Science, EarlyView.
A correlative imaging platform is developed to study how individual taste cells respond to different taste qualities. By linking cellular activity with molecular identity and environmental context, dual‐tuned taste cells capable of detecting both sweet and umami stimuli are identified.
Sungho Lee   +6 more
wiley   +1 more source

Una nova edició de l'Origen destinada al gran públic [PDF]

open access: yes, 2012
Una nova edició de l'Origen destinada al gran pú ...
Simón Fos Martín
core   +1 more source

Continuity and change in diocese and province: the role of a Tudor bishop [PDF]

open access: yes, 1996
Thomas Cranmer's register is important in shedding valuable shafts of light on the nature of the episcopal office in Tudor England. Despite the government's break with Rome in the 1530s, much of the archbishop's routine administration continued unaltered.
Ayris, P
core   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

open access: yesAdvanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang   +17 more
wiley   +1 more source

Fructooligosaccharides (FOS) intake modulates oxidative stress and restores gut morphology in Giardia lamblia-infected gerbils [PDF]

open access: yesAnais da Academia Brasileira de Ciências
The purpose of this study is to evaluate the effects of fructooligosaccharide (FOS) supplementation on the prevention of experimental giardiasis by analyzing morphological, biochemical, and parasitological parameters in a gerbil model.
MAYANA R.S. RIBEIRO   +4 more
doaj   +1 more source

Antidepressant-like effects induced by galanin 2/neuropeptide Y Y1 heterodimers in the dentate gyrus of the hippocampus [PDF]

open access: yes, 2017
Previously, we have described the Galanin (GAL) and Neuropeptide Y Y1 (NPYY1) interactions through GAL receptor 2 and NPYY1 receptor 1 (GALR2/NPYY1R) heterodimers in the Dentate Gyrus (DG) of the Hippocampus, using autoradiographic, in situ ...
Borroto-Escuela, Dasiel   +8 more
core  

A Short-Term Solar Photovoltaic Power Optimized Prediction Interval Model Based on FOS-ELM Algorithm [PDF]

open access: gold, 2021
G. Ramkumar   +7 more
openalex   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

open access: yesAdvanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu   +14 more
wiley   +1 more source

Expression of fos andjun genes in human skeletal muscle after exercise [PDF]

open access: bronze, 1998
A. Puntschart   +7 more
openalex   +1 more source

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